Abstract
AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.
| Original language | English |
|---|---|
| Pages (from-to) | 2873-2881 |
| Number of pages | 9 |
| Journal | European heart journal |
| Volume | 33 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2012 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography. / Shin, Sanghoon; Kim, Kwang Joon; Chang, Hyuk Jae; Cho, Iksung; Kim, Young Jin; Choi, Byoung Wook; Rhee, Yumie; Lim, Sung Kil; Yang, Woo In; Shim, Chi Young; Ha, Jong Won; Jang, Yangsoo; Chung, Namsik.
In: European heart journal, Vol. 33, No. 22, 01.11.2012, p. 2873-2881.Research output: Contribution to journal › Article
TY - JOUR
T1 - Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography
AU - Shin, Sanghoon
AU - Kim, Kwang Joon
AU - Chang, Hyuk Jae
AU - Cho, Iksung
AU - Kim, Young Jin
AU - Choi, Byoung Wook
AU - Rhee, Yumie
AU - Lim, Sung Kil
AU - Yang, Woo In
AU - Shim, Chi Young
AU - Ha, Jong Won
AU - Jang, Yangsoo
AU - Chung, Namsik
PY - 2012/11/1
Y1 - 2012/11/1
N2 - AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.
AB - AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.
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U2 - 10.1093/eurheartj/ehs152
DO - 10.1093/eurheartj/ehs152
M3 - Article
C2 - 22719023
AN - SCOPUS:84869410724
VL - 33
SP - 2873
EP - 2881
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 22
ER -