Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography

Sanghoon Shin, Kwang Joon Kim, Hyuk-Jae Chang, Iksung Cho, Youngjin Kim, Byoung Wook Choi, Yumie Rhee, Sungkil Lim, Woo In Yang, ChiYoung Shim, Jong Won Ha, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

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Abstract

AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.

Original languageEnglish
Pages (from-to)2873-2881
Number of pages9
JournalEuropean Heart Journal
Volume33
Issue number22
DOIs
Publication statusPublished - 2012 Nov 1

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Coronary Artery Disease
Tomography
Calcium
Serum
Odds Ratio
Kidney
Coronary Vessels
calcium phosphate
Vascular Calcification
Atherosclerotic Plaques
Glomerular Filtration Rate
Chronic Renal Insufficiency
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Shin, Sanghoon ; Kim, Kwang Joon ; Chang, Hyuk-Jae ; Cho, Iksung ; Kim, Youngjin ; Choi, Byoung Wook ; Rhee, Yumie ; Lim, Sungkil ; Yang, Woo In ; Shim, ChiYoung ; Ha, Jong Won ; Jang, Yangsoo ; Chung, Namsik. / Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography. In: European Heart Journal. 2012 ; Vol. 33, No. 22. pp. 2873-2881.
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abstract = "AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.",
author = "Sanghoon Shin and Kim, {Kwang Joon} and Hyuk-Jae Chang and Iksung Cho and Youngjin Kim and Choi, {Byoung Wook} and Yumie Rhee and Sungkil Lim and Yang, {Woo In} and ChiYoung Shim and Ha, {Jong Won} and Yangsoo Jang and Namsik Chung",
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Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography. / Shin, Sanghoon; Kim, Kwang Joon; Chang, Hyuk-Jae; Cho, Iksung; Kim, Youngjin; Choi, Byoung Wook; Rhee, Yumie; Lim, Sungkil; Yang, Woo In; Shim, ChiYoung; Ha, Jong Won; Jang, Yangsoo; Chung, Namsik.

In: European Heart Journal, Vol. 33, No. 22, 01.11.2012, p. 2873-2881.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography

AU - Shin, Sanghoon

AU - Kim, Kwang Joon

AU - Chang, Hyuk-Jae

AU - Cho, Iksung

AU - Kim, Youngjin

AU - Choi, Byoung Wook

AU - Rhee, Yumie

AU - Lim, Sungkil

AU - Yang, Woo In

AU - Shim, ChiYoung

AU - Ha, Jong Won

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2012/11/1

Y1 - 2012/11/1

N2 - AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.

AB - AimsHigh calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function.Methods and resultsThis study included 7553 participants (52 ± 10 years, male 57) with near-normal kidney function (estimated glomerular filtration rate > 60 mL/min/1.73 m 2) who underwent cCTA. The relationship of Ca, P, and CPP to coronary atherosclerosis [coronary artery Ca score (CACS) >100 and the presence of coronary artery disease (CAD)] was evaluated. Higher Ca, P, and CPP were significantly associated with CACS > 100 continuously [adjusted odds ratio (OR) per mg/dL: Ca 1.21, P = 0.026; P 1.29, P < 0.001; CPP 1.03, P < 0.001]. However, they correlate only weakly with the presence of CAD (OR: Ca 1.17, P = 0.001; P 1.05, P = 0.173; CPP 1.01, P = 0.034). This discrepancy was because calcified or mixed plaque and non-calcified plaque (NCP) were included in CAD. A significant relationship was demonstrated between calcified or mixed plaque and Ca, P, and CPP (OR: Ca 1.20, P = 0.001; P 1.13, P = 0.003; CPP 1.02, P = 0.001), but not NCP.ConclusionElevated serum levels of Ca, P, and CPP are significantly associated with the presence of calcified coronary atherosclerotic plaque. It is unclear if there is a causal relationship. This relationship is thought to contribute to vascular calcification, but is less closely associated with NCP.

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