Impact of splenectomy for lymph node dissection on long-term surgical outcome in gastric cancer

Kang Young Lee, Sung Hoon Noh, WooJin Hyung, Jun Ho Lee, Ki Hyeok Lah, Seung Ho Choi, Jin Sik Min

Research output: Contribution to journalArticle

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Abstract

Background: In the treatment of gastric cancer, splenectomy is performed for effective lymph node dissection around the splenic artery and splenic hilum. The purpose of this study was to clarify the long-term outcome of splenectomy in the treatment of gastric cancer. Methods: The effect of splenectomy on recurrence and prognosis was examined in a retrospective analysis of 665 patients who had undergone curative total gastrectomy for gastric carcinoma from 1987 to 1996. The risk factors associated with recurrence and prognosis were investigated by univariate and multivariate analysis. Results: The splenectomy group showed more advanced lesions and a higher recurrence rate than the spleen-preserved group. However, after adjusting for the TNM (tumor, node, metastasis) stage, there was no significant difference in recurrence rate and pattern between the two groups. Logistic regression analysis revealed that gross type, serosal invasion, and nodal metastasis were independent risk factors for recurrence while splenectomy was not. When comparing patients with the same TNM (tumor, node, metastasis) stages, no significant difference in the 5-year survival rates was apparent. Multivariate analysis demonstrated that age, serosal invasion, and nodal metastasis were independent prognostic factors whereas splenectomy was not. Conclusions: These data suggest that splenectomy for lymph node dissection in gastric cancer is not effective regarding long-term patient prognosis.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalAnnals of Surgical Oncology
Volume8
Issue number5
DOIs
Publication statusPublished - 2001 Jan 1

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Splenectomy
Lymph Node Excision
Stomach Neoplasms
Recurrence
Neoplasm Metastasis
Multivariate Analysis
Splenic Artery
Gastrectomy
Neoplasms
Stomach
Spleen
Survival Rate
Logistic Models
Regression Analysis
Carcinoma
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Lee, Kang Young ; Noh, Sung Hoon ; Hyung, WooJin ; Lee, Jun Ho ; Lah, Ki Hyeok ; Choi, Seung Ho ; Min, Jin Sik. / Impact of splenectomy for lymph node dissection on long-term surgical outcome in gastric cancer. In: Annals of Surgical Oncology. 2001 ; Vol. 8, No. 5. pp. 402-406.
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abstract = "Background: In the treatment of gastric cancer, splenectomy is performed for effective lymph node dissection around the splenic artery and splenic hilum. The purpose of this study was to clarify the long-term outcome of splenectomy in the treatment of gastric cancer. Methods: The effect of splenectomy on recurrence and prognosis was examined in a retrospective analysis of 665 patients who had undergone curative total gastrectomy for gastric carcinoma from 1987 to 1996. The risk factors associated with recurrence and prognosis were investigated by univariate and multivariate analysis. Results: The splenectomy group showed more advanced lesions and a higher recurrence rate than the spleen-preserved group. However, after adjusting for the TNM (tumor, node, metastasis) stage, there was no significant difference in recurrence rate and pattern between the two groups. Logistic regression analysis revealed that gross type, serosal invasion, and nodal metastasis were independent risk factors for recurrence while splenectomy was not. When comparing patients with the same TNM (tumor, node, metastasis) stages, no significant difference in the 5-year survival rates was apparent. Multivariate analysis demonstrated that age, serosal invasion, and nodal metastasis were independent prognostic factors whereas splenectomy was not. Conclusions: These data suggest that splenectomy for lymph node dissection in gastric cancer is not effective regarding long-term patient prognosis.",
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Impact of splenectomy for lymph node dissection on long-term surgical outcome in gastric cancer. / Lee, Kang Young; Noh, Sung Hoon; Hyung, WooJin; Lee, Jun Ho; Lah, Ki Hyeok; Choi, Seung Ho; Min, Jin Sik.

In: Annals of Surgical Oncology, Vol. 8, No. 5, 01.01.2001, p. 402-406.

Research output: Contribution to journalArticle

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AU - Lee, Kang Young

AU - Noh, Sung Hoon

AU - Hyung, WooJin

AU - Lee, Jun Ho

AU - Lah, Ki Hyeok

AU - Choi, Seung Ho

AU - Min, Jin Sik

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N2 - Background: In the treatment of gastric cancer, splenectomy is performed for effective lymph node dissection around the splenic artery and splenic hilum. The purpose of this study was to clarify the long-term outcome of splenectomy in the treatment of gastric cancer. Methods: The effect of splenectomy on recurrence and prognosis was examined in a retrospective analysis of 665 patients who had undergone curative total gastrectomy for gastric carcinoma from 1987 to 1996. The risk factors associated with recurrence and prognosis were investigated by univariate and multivariate analysis. Results: The splenectomy group showed more advanced lesions and a higher recurrence rate than the spleen-preserved group. However, after adjusting for the TNM (tumor, node, metastasis) stage, there was no significant difference in recurrence rate and pattern between the two groups. Logistic regression analysis revealed that gross type, serosal invasion, and nodal metastasis were independent risk factors for recurrence while splenectomy was not. When comparing patients with the same TNM (tumor, node, metastasis) stages, no significant difference in the 5-year survival rates was apparent. Multivariate analysis demonstrated that age, serosal invasion, and nodal metastasis were independent prognostic factors whereas splenectomy was not. Conclusions: These data suggest that splenectomy for lymph node dissection in gastric cancer is not effective regarding long-term patient prognosis.

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