Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer

Taeil Son, In Gyu Kwon, Joong Ho Lee, Youn Young Choi, Hyoung Il Kim, Jae Ho Cheong, Sung Hoon Noh, Woo Jin Hyung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. Study Design: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a). To investigate the survival benefit of performing splenic hilar LN dissection, the estimated therapeutic index for the procedure was calculated by multiplying the incidence of metastases in the hilar region by the survival rates for individuals with nodal involvement in that region. Results: Of 602 patients, 87(14.5%) had hilar LN metastasis. The 5-year overall and relapse-free survival rates for patients with hilar LN metastasis were 24.1% and 12.1%, respectively. These rates were similar to those for patients with metastasis to other extraperigastric LNs (P > 0.05), with similar recurrence patterns. Overall survival in the hilar LN metastasis group was better than that for patients with distant metastasis(P < 0.05). The estimated therapeutic index of splenic hilar LN dissection was 3.5, which was similar to index values for LN dissection at other extraperigastric LNs. Conclusions: Dissection of splenic hilar LNs during total gastrectomy for advanced gastric cancer allows for a prognosis similar to that achieved with dissection of extraperigastric LNs.

Original languageEnglish
Pages (from-to)84515-84528
Number of pages14
JournalOncotarget
Volume8
Issue number48
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Gastrectomy
Dissection
Survival Rate
Recurrence
Survival
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Son, Taeil ; Kwon, In Gyu ; Lee, Joong Ho ; Choi, Youn Young ; Kim, Hyoung Il ; Cheong, Jae Ho ; Noh, Sung Hoon ; Hyung, Woo Jin. / Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer. In: Oncotarget. 2017 ; Vol. 8, No. 48. pp. 84515-84528.
@article{c69f0ac4d25d46f4b2fae2ccc74998d6,
title = "Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer",
abstract = "Background: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. Study Design: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a). To investigate the survival benefit of performing splenic hilar LN dissection, the estimated therapeutic index for the procedure was calculated by multiplying the incidence of metastases in the hilar region by the survival rates for individuals with nodal involvement in that region. Results: Of 602 patients, 87(14.5{\%}) had hilar LN metastasis. The 5-year overall and relapse-free survival rates for patients with hilar LN metastasis were 24.1{\%} and 12.1{\%}, respectively. These rates were similar to those for patients with metastasis to other extraperigastric LNs (P > 0.05), with similar recurrence patterns. Overall survival in the hilar LN metastasis group was better than that for patients with distant metastasis(P < 0.05). The estimated therapeutic index of splenic hilar LN dissection was 3.5, which was similar to index values for LN dissection at other extraperigastric LNs. Conclusions: Dissection of splenic hilar LNs during total gastrectomy for advanced gastric cancer allows for a prognosis similar to that achieved with dissection of extraperigastric LNs.",
author = "Taeil Son and Kwon, {In Gyu} and Lee, {Joong Ho} and Choi, {Youn Young} and Kim, {Hyoung Il} and Cheong, {Jae Ho} and Noh, {Sung Hoon} and Hyung, {Woo Jin}",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.18762",
language = "English",
volume = "8",
pages = "84515--84528",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "48",

}

Son, T, Kwon, IG, Lee, JH, Choi, YY, Kim, HI, Cheong, JH, Noh, SH & Hyung, WJ 2017, 'Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer', Oncotarget, vol. 8, no. 48, pp. 84515-84528. https://doi.org/10.18632/oncotarget.18762

Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer. / Son, Taeil; Kwon, In Gyu; Lee, Joong Ho; Choi, Youn Young; Kim, Hyoung Il; Cheong, Jae Ho; Noh, Sung Hoon; Hyung, Woo Jin.

In: Oncotarget, Vol. 8, No. 48, 01.01.2017, p. 84515-84528.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer

AU - Son, Taeil

AU - Kwon, In Gyu

AU - Lee, Joong Ho

AU - Choi, Youn Young

AU - Kim, Hyoung Il

AU - Cheong, Jae Ho

AU - Noh, Sung Hoon

AU - Hyung, Woo Jin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. Study Design: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a). To investigate the survival benefit of performing splenic hilar LN dissection, the estimated therapeutic index for the procedure was calculated by multiplying the incidence of metastases in the hilar region by the survival rates for individuals with nodal involvement in that region. Results: Of 602 patients, 87(14.5%) had hilar LN metastasis. The 5-year overall and relapse-free survival rates for patients with hilar LN metastasis were 24.1% and 12.1%, respectively. These rates were similar to those for patients with metastasis to other extraperigastric LNs (P > 0.05), with similar recurrence patterns. Overall survival in the hilar LN metastasis group was better than that for patients with distant metastasis(P < 0.05). The estimated therapeutic index of splenic hilar LN dissection was 3.5, which was similar to index values for LN dissection at other extraperigastric LNs. Conclusions: Dissection of splenic hilar LNs during total gastrectomy for advanced gastric cancer allows for a prognosis similar to that achieved with dissection of extraperigastric LNs.

AB - Background: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. Study Design: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a). To investigate the survival benefit of performing splenic hilar LN dissection, the estimated therapeutic index for the procedure was calculated by multiplying the incidence of metastases in the hilar region by the survival rates for individuals with nodal involvement in that region. Results: Of 602 patients, 87(14.5%) had hilar LN metastasis. The 5-year overall and relapse-free survival rates for patients with hilar LN metastasis were 24.1% and 12.1%, respectively. These rates were similar to those for patients with metastasis to other extraperigastric LNs (P > 0.05), with similar recurrence patterns. Overall survival in the hilar LN metastasis group was better than that for patients with distant metastasis(P < 0.05). The estimated therapeutic index of splenic hilar LN dissection was 3.5, which was similar to index values for LN dissection at other extraperigastric LNs. Conclusions: Dissection of splenic hilar LNs during total gastrectomy for advanced gastric cancer allows for a prognosis similar to that achieved with dissection of extraperigastric LNs.

UR - http://www.scopus.com/inward/record.url?scp=85031041004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031041004&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.18762

DO - 10.18632/oncotarget.18762

M3 - Article

AN - SCOPUS:85031041004

VL - 8

SP - 84515

EP - 84528

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 48

ER -