Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects

Young Joo Park, You Jin Lee, Sang Il Choi, Eun Ju Chun, Hak Chul Jang, Hyuk Jae Chang

Research output: Contribution to journalArticle

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Abstract

Objective: Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CAD), as detected by cardiac computed tomography (CT), in apparently healthy subjects. Subjects and methods: We retrospectively enrolled 2404 asymptomatic subjects who underwent cardiac CT with an intermediate to high risk (Framingham 10-year risk ≥ 10%) of developing CAD but with no known CAD or thyroid disease. Coronary artery calciumscore (CACS) was assessed by calcium scan, and the presence of the plaques (CAD), with ≥ 50% stenosis being indicative of obstructive CAD, was assessed by coronary CT angiography. Results: Of the 2404 subjects, 2355 subjects were euthyroid (Eu; 53 ± 9 years, 83 females) and 49 had SCH (58 ± 12 years, seven females). CAD and CACS > 100 were more prevalent in SCH subjects than in Eu subjects (Eu vs SCH: CAD, 948 (40.6%) vs 31 (63.3%), P = 0.002; CACS > 100, 239 (10.3%) vs 10 (20.4%), P = 0.031). SCH was also an independent risk factor for CAD after a multivariate analysis (odds ratio: 2.125, 95% confidence interval: 1.049-4.307, P = 0.036). Conclusions: SCH subjects who were at an intermediate-to-high risk of developing CAD were significantly more likely to exhibit occult CAD than Eu subjects, especially inmen with SCH. These findings suggest that mild thyroid failure also independently contributes to the development of CAD.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalEuropean Journal of Endocrinology
Volume165
Issue number1
DOIs
Publication statusPublished - 2011 Jul 1

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Hypothyroidism
Coronary Artery Disease
Healthy Volunteers
Coronary Vessels
Thyroid Gland
Cardiovascular Diseases
Tomography
Thyroid Diseases
Pathologic Constriction
Multivariate Analysis
Odds Ratio
Confidence Intervals
Calcium

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Park, Young Joo ; Lee, You Jin ; Choi, Sang Il ; Chun, Eun Ju ; Jang, Hak Chul ; Chang, Hyuk Jae. / Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects. In: European Journal of Endocrinology. 2011 ; Vol. 165, No. 1. pp. 115-121.
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abstract = "Objective: Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CAD), as detected by cardiac computed tomography (CT), in apparently healthy subjects. Subjects and methods: We retrospectively enrolled 2404 asymptomatic subjects who underwent cardiac CT with an intermediate to high risk (Framingham 10-year risk ≥ 10{\%}) of developing CAD but with no known CAD or thyroid disease. Coronary artery calciumscore (CACS) was assessed by calcium scan, and the presence of the plaques (CAD), with ≥ 50{\%} stenosis being indicative of obstructive CAD, was assessed by coronary CT angiography. Results: Of the 2404 subjects, 2355 subjects were euthyroid (Eu; 53 ± 9 years, 83 females) and 49 had SCH (58 ± 12 years, seven females). CAD and CACS > 100 were more prevalent in SCH subjects than in Eu subjects (Eu vs SCH: CAD, 948 (40.6{\%}) vs 31 (63.3{\%}), P = 0.002; CACS > 100, 239 (10.3{\%}) vs 10 (20.4{\%}), P = 0.031). SCH was also an independent risk factor for CAD after a multivariate analysis (odds ratio: 2.125, 95{\%} confidence interval: 1.049-4.307, P = 0.036). Conclusions: SCH subjects who were at an intermediate-to-high risk of developing CAD were significantly more likely to exhibit occult CAD than Eu subjects, especially inmen with SCH. These findings suggest that mild thyroid failure also independently contributes to the development of CAD.",
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Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects. / Park, Young Joo; Lee, You Jin; Choi, Sang Il; Chun, Eun Ju; Jang, Hak Chul; Chang, Hyuk Jae.

In: European Journal of Endocrinology, Vol. 165, No. 1, 01.07.2011, p. 115-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects

AU - Park, Young Joo

AU - Lee, You Jin

AU - Choi, Sang Il

AU - Chun, Eun Ju

AU - Jang, Hak Chul

AU - Chang, Hyuk Jae

PY - 2011/7/1

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N2 - Objective: Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CAD), as detected by cardiac computed tomography (CT), in apparently healthy subjects. Subjects and methods: We retrospectively enrolled 2404 asymptomatic subjects who underwent cardiac CT with an intermediate to high risk (Framingham 10-year risk ≥ 10%) of developing CAD but with no known CAD or thyroid disease. Coronary artery calciumscore (CACS) was assessed by calcium scan, and the presence of the plaques (CAD), with ≥ 50% stenosis being indicative of obstructive CAD, was assessed by coronary CT angiography. Results: Of the 2404 subjects, 2355 subjects were euthyroid (Eu; 53 ± 9 years, 83 females) and 49 had SCH (58 ± 12 years, seven females). CAD and CACS > 100 were more prevalent in SCH subjects than in Eu subjects (Eu vs SCH: CAD, 948 (40.6%) vs 31 (63.3%), P = 0.002; CACS > 100, 239 (10.3%) vs 10 (20.4%), P = 0.031). SCH was also an independent risk factor for CAD after a multivariate analysis (odds ratio: 2.125, 95% confidence interval: 1.049-4.307, P = 0.036). Conclusions: SCH subjects who were at an intermediate-to-high risk of developing CAD were significantly more likely to exhibit occult CAD than Eu subjects, especially inmen with SCH. These findings suggest that mild thyroid failure also independently contributes to the development of CAD.

AB - Objective: Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CAD), as detected by cardiac computed tomography (CT), in apparently healthy subjects. Subjects and methods: We retrospectively enrolled 2404 asymptomatic subjects who underwent cardiac CT with an intermediate to high risk (Framingham 10-year risk ≥ 10%) of developing CAD but with no known CAD or thyroid disease. Coronary artery calciumscore (CACS) was assessed by calcium scan, and the presence of the plaques (CAD), with ≥ 50% stenosis being indicative of obstructive CAD, was assessed by coronary CT angiography. Results: Of the 2404 subjects, 2355 subjects were euthyroid (Eu; 53 ± 9 years, 83 females) and 49 had SCH (58 ± 12 years, seven females). CAD and CACS > 100 were more prevalent in SCH subjects than in Eu subjects (Eu vs SCH: CAD, 948 (40.6%) vs 31 (63.3%), P = 0.002; CACS > 100, 239 (10.3%) vs 10 (20.4%), P = 0.031). SCH was also an independent risk factor for CAD after a multivariate analysis (odds ratio: 2.125, 95% confidence interval: 1.049-4.307, P = 0.036). Conclusions: SCH subjects who were at an intermediate-to-high risk of developing CAD were significantly more likely to exhibit occult CAD than Eu subjects, especially inmen with SCH. These findings suggest that mild thyroid failure also independently contributes to the development of CAD.

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