Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis

Young Hak Kim, Duk Woo Park, Won Jang Kim, Jong Young Lee, Sung Cheol Yun, Soo Jin Kang, Seung Whan Lee, Cheol Whan Lee, Myeongki Hong, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: This study was designed to examine the impact of the extent of coronary disease on long-term outcomes after coronary stenting or coronary artery bypass graft (CABG) surgery for unprotected left main coronary artery (ULMCA) stenosis. Background: The differential outcome of ULMCA revascularization according to the coronary involvement remains uncertain. Methods: From the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, 2,240 patients with ULMCA stenosis who underwent either stenting or CABG were stratified by number of diseased vessels. Results: Following adjustment with EuroSCORE (European System for Cardiac Operative Risk Evaluation), diabetes mellitus, and bifurcation stenosis, stents and CABG had similar risks of death and major adverse cardiac events including death, Q-wave myocardial infarction, or stroke in all subgroups regardless of the number of diseased vessels over 4 years. In patients with 2-vessel (23.0% vs. 14.2%; hazard ratio [HR]: 1.739; 95% confidence interval [CI]: 1.171 to 2.582; p = 0.006) or 3-vessel (25.0% vs. 17.6%; HR: 1.493; 95% CI: 1.096 to 2.035; p = 0.011) disease, however, stenting was associated with a higher risk of major adverse cardiac and cerebrovascular events including major adverse cardiac events or target vessel revascularization than CABG. Interaction of vascular involvement with type of stent or CABG was not significant. Conclusions: Stenting appears to be a safe alternative to CABG in patients having ULMCA stenosis combined with additional vascular disease. The advantage of CABG over stenting lies principally in the reduction of repeat revascularization across subgroups stratified by the number of diseased vessels.

Original languageEnglish
Pages (from-to)2544-2552
Number of pages9
JournalJournal of the American College of Cardiology
Volume55
Issue number23
DOIs
Publication statusPublished - 2010 Jun 8

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Coronary Stenosis
Coronary Artery Bypass
Coronary Artery Disease
Transplants
Stents
Confidence Intervals
Vascular Diseases
Angioplasty
Coronary Disease
Blood Vessels
Registries
Coronary Vessels
Diabetes Mellitus
Pathologic Constriction
Stroke
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Young Hak ; Park, Duk Woo ; Kim, Won Jang ; Lee, Jong Young ; Yun, Sung Cheol ; Kang, Soo Jin ; Lee, Seung Whan ; Lee, Cheol Whan ; Hong, Myeongki ; Park, Seong Wook ; Park, Seung Jung. / Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis. In: Journal of the American College of Cardiology. 2010 ; Vol. 55, No. 23. pp. 2544-2552.
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abstract = "Objectives: This study was designed to examine the impact of the extent of coronary disease on long-term outcomes after coronary stenting or coronary artery bypass graft (CABG) surgery for unprotected left main coronary artery (ULMCA) stenosis. Background: The differential outcome of ULMCA revascularization according to the coronary involvement remains uncertain. Methods: From the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, 2,240 patients with ULMCA stenosis who underwent either stenting or CABG were stratified by number of diseased vessels. Results: Following adjustment with EuroSCORE (European System for Cardiac Operative Risk Evaluation), diabetes mellitus, and bifurcation stenosis, stents and CABG had similar risks of death and major adverse cardiac events including death, Q-wave myocardial infarction, or stroke in all subgroups regardless of the number of diseased vessels over 4 years. In patients with 2-vessel (23.0{\%} vs. 14.2{\%}; hazard ratio [HR]: 1.739; 95{\%} confidence interval [CI]: 1.171 to 2.582; p = 0.006) or 3-vessel (25.0{\%} vs. 17.6{\%}; HR: 1.493; 95{\%} CI: 1.096 to 2.035; p = 0.011) disease, however, stenting was associated with a higher risk of major adverse cardiac and cerebrovascular events including major adverse cardiac events or target vessel revascularization than CABG. Interaction of vascular involvement with type of stent or CABG was not significant. Conclusions: Stenting appears to be a safe alternative to CABG in patients having ULMCA stenosis combined with additional vascular disease. The advantage of CABG over stenting lies principally in the reduction of repeat revascularization across subgroups stratified by the number of diseased vessels.",
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Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis. / Kim, Young Hak; Park, Duk Woo; Kim, Won Jang; Lee, Jong Young; Yun, Sung Cheol; Kang, Soo Jin; Lee, Seung Whan; Lee, Cheol Whan; Hong, Myeongki; Park, Seong Wook; Park, Seung Jung.

In: Journal of the American College of Cardiology, Vol. 55, No. 23, 08.06.2010, p. 2544-2552.

Research output: Contribution to journalArticle

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T1 - Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis

AU - Kim, Young Hak

AU - Park, Duk Woo

AU - Kim, Won Jang

AU - Lee, Jong Young

AU - Yun, Sung Cheol

AU - Kang, Soo Jin

AU - Lee, Seung Whan

AU - Lee, Cheol Whan

AU - Hong, Myeongki

AU - Park, Seong Wook

AU - Park, Seung Jung

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Y1 - 2010/6/8

N2 - Objectives: This study was designed to examine the impact of the extent of coronary disease on long-term outcomes after coronary stenting or coronary artery bypass graft (CABG) surgery for unprotected left main coronary artery (ULMCA) stenosis. Background: The differential outcome of ULMCA revascularization according to the coronary involvement remains uncertain. Methods: From the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, 2,240 patients with ULMCA stenosis who underwent either stenting or CABG were stratified by number of diseased vessels. Results: Following adjustment with EuroSCORE (European System for Cardiac Operative Risk Evaluation), diabetes mellitus, and bifurcation stenosis, stents and CABG had similar risks of death and major adverse cardiac events including death, Q-wave myocardial infarction, or stroke in all subgroups regardless of the number of diseased vessels over 4 years. In patients with 2-vessel (23.0% vs. 14.2%; hazard ratio [HR]: 1.739; 95% confidence interval [CI]: 1.171 to 2.582; p = 0.006) or 3-vessel (25.0% vs. 17.6%; HR: 1.493; 95% CI: 1.096 to 2.035; p = 0.011) disease, however, stenting was associated with a higher risk of major adverse cardiac and cerebrovascular events including major adverse cardiac events or target vessel revascularization than CABG. Interaction of vascular involvement with type of stent or CABG was not significant. Conclusions: Stenting appears to be a safe alternative to CABG in patients having ULMCA stenosis combined with additional vascular disease. The advantage of CABG over stenting lies principally in the reduction of repeat revascularization across subgroups stratified by the number of diseased vessels.

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