Impact of toxocariasis in patients with unexplained patchy pulmonary infiltrate in Korea

Young Soon Yoon, Chang Hoon Lee, youngae kang, Sung Youn Kwon, Ho II Yoon, Jae Ho Lee, Choon Taek Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Toxocariasis is one of the causes of pulmonary eosinophilic infiltrate that is increasing in Korea. This study was designed to identify the prevalence of toxocara seropositivity in patients with unexplained pulmonary patchy infiltrate and to evaluate associated factors. We evaluated 102 patients with unexplained pulmonary patchy infiltrate on chest computed tomography (CT) scan. As a control set, 116 subjects with normal chest CT were also evaluated. History of allergic disease, drug use, parasitic disease and raw cow liver intake were taken. Blood eosinophil count and total IgE level were measured. Specific serum IgG antibody to Toxocara canis larval antigen and specific IgG antibodies to 4 other parasites were measured by enzymelinked immunosorbent assay (ELISA). In the infiltrate group, 66.7% subjects were toxocara seropositive whereas 22.4% of the control group were seropositive (p< 0.001). In the infiltrate group, patients with a history of eating raw cow liver (odds ratio [OR], 7.8) and patients with eosinophilia (OR, 5.2) had a higher incidence of toxocara seropositivity. Thirty-five percent of toxocara seropositive patients with infiltrate exhibited migrating infiltrate and 48% had decreased infiltrate on the follow-up CT. We recommend that toxocara ELISA should be performed in patients with unexplained pulmonary patchy infiltrate, and that the eating of raw cow liver should be actively discouraged.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalJournal of Korean medical science
Volume24
Issue number1
DOIs
Publication statusPublished - 2009 Feb 1

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Toxocariasis
Toxocara
Korea
Lung
Immunosorbents
Tomography
Liver
Thorax
Eating
Immunoglobulin G
Odds Ratio
Toxocara canis
Parasitic Diseases
Antibodies
Eosinophilia
Eosinophils
Immunoglobulin E
Parasites
Antigens
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoon, Young Soon ; Lee, Chang Hoon ; kang, youngae ; Kwon, Sung Youn ; Yoon, Ho II ; Lee, Jae Ho ; Lee, Choon Taek. / Impact of toxocariasis in patients with unexplained patchy pulmonary infiltrate in Korea. In: Journal of Korean medical science. 2009 ; Vol. 24, No. 1. pp. 40-45.
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Impact of toxocariasis in patients with unexplained patchy pulmonary infiltrate in Korea. / Yoon, Young Soon; Lee, Chang Hoon; kang, youngae; Kwon, Sung Youn; Yoon, Ho II; Lee, Jae Ho; Lee, Choon Taek.

In: Journal of Korean medical science, Vol. 24, No. 1, 01.02.2009, p. 40-45.

Research output: Contribution to journalArticle

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