Impaired visuospatial attention revealed by theta- and beta-band cortical activities in idiopathic REM sleep behavior disorder patients

Seongjin Her, Kwang Su Cha, Jeong Woo Choi, Hyun Kim, Jung Ick Byun, Jun Sang Sunwoo, Tae Joon Kim, Jung Ah Lim, Ki Young Jung, Kyung Hwan Kim

Research output: Contribution to journalArticle

Abstract

Objectives: Idiopathic REM sleep behavior disorder (iRBD) patients are susceptible to cognitive deficits, especially attention dysfunction. The objective of this study is to elucidate the neural mechanism of the dysfunction in attention known as ‘inhibition of return’ (IOR) in iRBD patients based on an analysis of oscillatory cortical activity during a selective attention task. Methods: Event-related potentials (ERPs) were recorded from iRBD patients and normal control subjects while performing a Posner task. The differences in N1 ERP and theta- and beta-bands event-related spectral perturbations (ERSPs) between valid and invalid stimuli were compared between groups. Results: The N1 amplitude was significantly higher for the invalid stimuli in controls, while the valid-invalid difference was not significant in iRBD patients. The valid-invalid differences in ERSPs were prominent in controls at ∼100–400 ms for the theta-band and ∼200–400 ms for the beta-band, and the valid-invalid differences in ERSPs were not significant in the iRBD patients. Conclusion: The results demonstrated that valid-invalid differences in neural activity were absent in iRBD patients, and these neural findings were in accord with the behavioral results. Significance: Our findings imply impairment in sensory-perceptual processing mediated by attentional control and response inhibition in early-stage iRBD before clinical neurodegeneration.

Original languageEnglish
Pages (from-to)1962-1970
Number of pages9
JournalClinical Neurophysiology
Volume130
Issue number10
DOIs
Publication statusPublished - 2019 Oct

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REM Sleep Behavior Disorder
Evoked Potentials

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Her, Seongjin ; Cha, Kwang Su ; Choi, Jeong Woo ; Kim, Hyun ; Byun, Jung Ick ; Sunwoo, Jun Sang ; Kim, Tae Joon ; Lim, Jung Ah ; Jung, Ki Young ; Kim, Kyung Hwan. / Impaired visuospatial attention revealed by theta- and beta-band cortical activities in idiopathic REM sleep behavior disorder patients. In: Clinical Neurophysiology. 2019 ; Vol. 130, No. 10. pp. 1962-1970.
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abstract = "Objectives: Idiopathic REM sleep behavior disorder (iRBD) patients are susceptible to cognitive deficits, especially attention dysfunction. The objective of this study is to elucidate the neural mechanism of the dysfunction in attention known as ‘inhibition of return’ (IOR) in iRBD patients based on an analysis of oscillatory cortical activity during a selective attention task. Methods: Event-related potentials (ERPs) were recorded from iRBD patients and normal control subjects while performing a Posner task. The differences in N1 ERP and theta- and beta-bands event-related spectral perturbations (ERSPs) between valid and invalid stimuli were compared between groups. Results: The N1 amplitude was significantly higher for the invalid stimuli in controls, while the valid-invalid difference was not significant in iRBD patients. The valid-invalid differences in ERSPs were prominent in controls at ∼100–400 ms for the theta-band and ∼200–400 ms for the beta-band, and the valid-invalid differences in ERSPs were not significant in the iRBD patients. Conclusion: The results demonstrated that valid-invalid differences in neural activity were absent in iRBD patients, and these neural findings were in accord with the behavioral results. Significance: Our findings imply impairment in sensory-perceptual processing mediated by attentional control and response inhibition in early-stage iRBD before clinical neurodegeneration.",
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Impaired visuospatial attention revealed by theta- and beta-band cortical activities in idiopathic REM sleep behavior disorder patients. / Her, Seongjin; Cha, Kwang Su; Choi, Jeong Woo; Kim, Hyun; Byun, Jung Ick; Sunwoo, Jun Sang; Kim, Tae Joon; Lim, Jung Ah; Jung, Ki Young; Kim, Kyung Hwan.

In: Clinical Neurophysiology, Vol. 130, No. 10, 10.2019, p. 1962-1970.

Research output: Contribution to journalArticle

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