Abstract
Tumor may arise from the dysregulation of immune system, which plays pivotal roles in counteracting tumor colonization, late-stage tumors, and metastases. In the midst of the establishment of cancer in vivo, immune cells are activated to release a multitude of immunokines, such as cytokines, and chemokines. Thus, since cytokine levels in tumor bearing host would be differential among local (intratumoral lesion, peritumoral normal tissue), and systemic sample site (serum), these differences might be significantly correlated to prognosis and treatment outcome for cancer patients. Previously, despite small number of patients, we demonstrated the feasibility of this proposition via only cytokine profiling. Based on this, herein we propose that immunokine profiling would be used as a surrogate, predictive tool for cancer staging, and progression.
| Original language | English |
|---|---|
| Pages (from-to) | 46-48 |
| Number of pages | 3 |
| Journal | Medical Hypotheses |
| Volume | 88 |
| DOIs | |
| Publication status | Published - 2016 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Implication of immunokine profiling for cancer staging. / Park, Kawngwoo; Dhupal, Madhusmita; Kim, Cheol Su; Park, Yoon Sun; Kim, Soo-Ki.
In: Medical Hypotheses, Vol. 88, 01.03.2016, p. 46-48.Research output: Contribution to journal › Article
TY - JOUR
T1 - Implication of immunokine profiling for cancer staging
AU - Park, Kawngwoo
AU - Dhupal, Madhusmita
AU - Kim, Cheol Su
AU - Park, Yoon Sun
AU - Kim, Soo-Ki
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Tumor may arise from the dysregulation of immune system, which plays pivotal roles in counteracting tumor colonization, late-stage tumors, and metastases. In the midst of the establishment of cancer in vivo, immune cells are activated to release a multitude of immunokines, such as cytokines, and chemokines. Thus, since cytokine levels in tumor bearing host would be differential among local (intratumoral lesion, peritumoral normal tissue), and systemic sample site (serum), these differences might be significantly correlated to prognosis and treatment outcome for cancer patients. Previously, despite small number of patients, we demonstrated the feasibility of this proposition via only cytokine profiling. Based on this, herein we propose that immunokine profiling would be used as a surrogate, predictive tool for cancer staging, and progression.
AB - Tumor may arise from the dysregulation of immune system, which plays pivotal roles in counteracting tumor colonization, late-stage tumors, and metastases. In the midst of the establishment of cancer in vivo, immune cells are activated to release a multitude of immunokines, such as cytokines, and chemokines. Thus, since cytokine levels in tumor bearing host would be differential among local (intratumoral lesion, peritumoral normal tissue), and systemic sample site (serum), these differences might be significantly correlated to prognosis and treatment outcome for cancer patients. Previously, despite small number of patients, we demonstrated the feasibility of this proposition via only cytokine profiling. Based on this, herein we propose that immunokine profiling would be used as a surrogate, predictive tool for cancer staging, and progression.
UR - http://www.scopus.com/inward/record.url?scp=84958206136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958206136&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2016.01.005
DO - 10.1016/j.mehy.2016.01.005
M3 - Article
C2 - 26880636
AN - SCOPUS:84958206136
VL - 88
SP - 46
EP - 48
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
ER -