Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease

S. Y. Kim, B. Chang, B. H. Jeong, H. Y. Park, K. Jeon, S. J. Shin, W. J. Koh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

BACKGROUND: Little information is available regarding Vitamin D-associated factors in patients with nontuberculous mycobacteria (NTM) lung disease. O B JE C T IVE : To determine the association between Vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), Vitamin D receptor (VDR) and 1a-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyVitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and Vitamin Dbinding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULT S : Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum Vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUS ION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum Vitamin D status.

Original languageEnglish
Pages (from-to)1594-1602
Number of pages9
JournalInternational Journal of Tuberculosis and Lung Disease
Volume20
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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