Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease

S. Y. Kim, B. Chang, B. H. Jeong, H. Y. Park, K. Jeon, SungJae Shin, W. J. Koh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Little information is available regarding Vitamin D-associated factors in patients with nontuberculous mycobacteria (NTM) lung disease. O B JE C T IVE : To determine the association between Vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), Vitamin D receptor (VDR) and 1a-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyVitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and Vitamin Dbinding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULT S : Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum Vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUS ION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum Vitamin D status.

Original languageEnglish
Pages (from-to)1594-1602
Number of pages9
JournalInternational Journal of Tuberculosis and Lung Disease
Volume20
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Nontuberculous Mycobacteria
Vitamin D
Lung Diseases
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Calcitriol Receptors
Gene Expression
Defensins
Serum
Mixed Function Oxygenases
Vitamins
Blood Proteins
Proteins
Peptides

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Kim, S. Y. ; Chang, B. ; Jeong, B. H. ; Park, H. Y. ; Jeon, K. ; Shin, SungJae ; Koh, W. J. / Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease. In: International Journal of Tuberculosis and Lung Disease. 2016 ; Vol. 20, No. 12. pp. 1594-1602.
@article{8d3818830a4d4e64877b40cc395c77b9,
title = "Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease",
abstract = "BACKGROUND: Little information is available regarding Vitamin D-associated factors in patients with nontuberculous mycobacteria (NTM) lung disease. O B JE C T IVE : To determine the association between Vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), Vitamin D receptor (VDR) and 1a-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyVitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and Vitamin Dbinding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULT S : Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum Vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUS ION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum Vitamin D status.",
author = "Kim, {S. Y.} and B. Chang and Jeong, {B. H.} and Park, {H. Y.} and K. Jeon and SungJae Shin and Koh, {W. J.}",
year = "2016",
month = "12",
day = "1",
doi = "10.5588/ijtld.16.0347",
language = "English",
volume = "20",
pages = "1594--1602",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "12",

}

Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease. / Kim, S. Y.; Chang, B.; Jeong, B. H.; Park, H. Y.; Jeon, K.; Shin, SungJae; Koh, W. J.

In: International Journal of Tuberculosis and Lung Disease, Vol. 20, No. 12, 01.12.2016, p. 1594-1602.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Implication of Vitamin D-associated factors in patients with nontuberculous mycobacterial lung disease

AU - Kim, S. Y.

AU - Chang, B.

AU - Jeong, B. H.

AU - Park, H. Y.

AU - Jeon, K.

AU - Shin, SungJae

AU - Koh, W. J.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - BACKGROUND: Little information is available regarding Vitamin D-associated factors in patients with nontuberculous mycobacteria (NTM) lung disease. O B JE C T IVE : To determine the association between Vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), Vitamin D receptor (VDR) and 1a-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyVitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and Vitamin Dbinding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULT S : Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum Vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUS ION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum Vitamin D status.

AB - BACKGROUND: Little information is available regarding Vitamin D-associated factors in patients with nontuberculous mycobacteria (NTM) lung disease. O B JE C T IVE : To determine the association between Vitamin D-related factors and susceptibility to NTM lung disease. DESIGN: The relative gene expression levels of cathelicidin (CAMP), defensin (DEFB4), Vitamin D receptor (VDR) and 1a-hydroxylase (CYP27B1), as well as the serum levels of 25-hydroxyVitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and Vitamin Dbinding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed. RESULT S : Gene expression of CAMP and DEFB4 was significantly higher, and gene expression of VDR and CYP27B1 was significantly lower, in NTM patients than controls. Serum LL-37 and hBD-2 levels were not significantly different between NTM patients and controls; however, the serum DBP level was higher in NTM patients than controls. The serum Vitamin D status of patients did not correlate with serum LL-37, hBD-2, or DBP concentration or gene expression of CAMP, DEFB4, VDR or CYP27B1. CONCLUS ION: A higher level of gene expression for antimicrobial peptide is more likely to be associated with NTM lung disease than serum Vitamin D status.

UR - http://www.scopus.com/inward/record.url?scp=84999048202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84999048202&partnerID=8YFLogxK

U2 - 10.5588/ijtld.16.0347

DO - 10.5588/ijtld.16.0347

M3 - Article

VL - 20

SP - 1594

EP - 1602

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 12

ER -