Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer

Sang Joon Shin, Joong Bae Ahn, Jin Sub Choi, Gi Hong Choi, Kang Young Lee, Seung Hyuk Baik, Byung Soh Min, Hyuk Hur, Jae Kyung Roh, Nam Kyu Kim

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Objective/background: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met"astases (CLM). Method: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. Results: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81%) had a low CRS (0-2) and 47 (19%) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5% and 11.5% among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4%) improved disease-free survival and overall survival. Conclusion: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.

Original languageEnglish
Pages (from-to)e125-e130
JournalSurgical Oncology
Volume21
Issue number3
DOIs
Publication statusPublished - 2012 Sep 1

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Colorectal Neoplasms
Neoplasm Metastasis
Liver
Induction Chemotherapy
Survival
Disease-Free Survival
Therapeutics
Survival Rate
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Shin, Sang Joon ; Ahn, Joong Bae ; Choi, Jin Sub ; Choi, Gi Hong ; Lee, Kang Young ; Baik, Seung Hyuk ; Min, Byung Soh ; Hur, Hyuk ; Roh, Jae Kyung ; Kim, Nam Kyu. / Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer. In: Surgical Oncology. 2012 ; Vol. 21, No. 3. pp. e125-e130.
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abstract = "Objective/background: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met{"}astases (CLM). Method: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. Results: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81{\%}) had a low CRS (0-2) and 47 (19{\%}) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5{\%} and 11.5{\%} among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4{\%}) improved disease-free survival and overall survival. Conclusion: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.",
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Shin, SJ, Ahn, JB, Choi, JS, Choi, GH, Lee, KY, Baik, SH, Min, BS, Hur, H, Roh, JK & Kim, NK 2012, 'Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer', Surgical Oncology, vol. 21, no. 3, pp. e125-e130. https://doi.org/10.1016/j.suronc.2012.04.002

Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer. / Shin, Sang Joon; Ahn, Joong Bae; Choi, Jin Sub; Choi, Gi Hong; Lee, Kang Young; Baik, Seung Hyuk; Min, Byung Soh; Hur, Hyuk; Roh, Jae Kyung; Kim, Nam Kyu.

In: Surgical Oncology, Vol. 21, No. 3, 01.09.2012, p. e125-e130.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer

AU - Shin, Sang Joon

AU - Ahn, Joong Bae

AU - Choi, Jin Sub

AU - Choi, Gi Hong

AU - Lee, Kang Young

AU - Baik, Seung Hyuk

AU - Min, Byung Soh

AU - Hur, Hyuk

AU - Roh, Jae Kyung

AU - Kim, Nam Kyu

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Objective/background: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met"astases (CLM). Method: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. Results: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81%) had a low CRS (0-2) and 47 (19%) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5% and 11.5% among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4%) improved disease-free survival and overall survival. Conclusion: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.

AB - Objective/background: We investigated the usefulness of a clinical risk scoring system (CRS) for guiding management and defining prognosis for patients with colorectal liver met"astases (CLM). Method: We retrospectively analyzed data about the correlation between outcomes and Fong's CRS from 1989 to 2010 for patients treated for CLM at the Severance Hospital. Results: Of 566 patients, 232 received adjuvant treatment after liver resection. Of these patients, 185 (81%) had a low CRS (0-2) and 47 (19%) had a high CRS (3-5). Stratification into high and low CRS allowed significant distinction between Kaplan-Meier curves for outcome. The 5-year survival rate was 88.5% and 11.5% among patients with a low and high CRS, respectively (P < 0.001). Seventy patients with initially unresectable CLM underwent liver resection after tumor downsizing by induction chemotherapy. Shifting of the CRS from high to low (8 patients; 11.4%) improved disease-free survival and overall survival. Conclusion: High CRS is associated with worse survival after resection in resectable and unresectable disease. The CRS may be used for risk assessment when recommending oncological surgical timing in initially unresectable disease and treatment options for perioperative or adjuvant treatment in resectable disease.

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