Implications of the nucleosome code in regulatory variation, adaptation and evolution.

Jung Kyoon Choi, Young Joon Kim

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Despite its importance in transcriptional regulation, only recently has epigenetics attracted attention in the research of genomic expression variation and evolution. Recent studies suggested that positioned nucleosomes in a specific region of the promoter are associated with regulatory variation, regardless of being stochastic, environmental, genetic or evolutionary. Further, this intrinsically variable transcriptional pattern was proposed to be hardwired in the underlying promoter sequences that govern nucleosome organization. It seems that this nucleosome code for intrinsic variation is essential in the regulatory control of stress response. Stochastic remodeling of cis-encoded nucleosomes could provide transcriptional plasticity and resilience to transient environmental stresses. In response to long-term environmental challenges, however, genetic adaptation of the nucleosome code might lead to a converged epigenetic state, translating short-term adaptation into evolutionary adaptation. This is supported by the observation that the relevant nucleosome codes in the genomes of yeast species reflect their phylogenetic relationships.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalEpigenetics : official journal of the DNA Methylation Society
Volume4
Issue number5
DOIs
Publication statusPublished - 2009 Jul 1

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Nucleosomes
Epigenomics
Genetic Promoter Regions
Yeasts
Genome
Research

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cancer Research

Cite this

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title = "Implications of the nucleosome code in regulatory variation, adaptation and evolution.",
abstract = "Despite its importance in transcriptional regulation, only recently has epigenetics attracted attention in the research of genomic expression variation and evolution. Recent studies suggested that positioned nucleosomes in a specific region of the promoter are associated with regulatory variation, regardless of being stochastic, environmental, genetic or evolutionary. Further, this intrinsically variable transcriptional pattern was proposed to be hardwired in the underlying promoter sequences that govern nucleosome organization. It seems that this nucleosome code for intrinsic variation is essential in the regulatory control of stress response. Stochastic remodeling of cis-encoded nucleosomes could provide transcriptional plasticity and resilience to transient environmental stresses. In response to long-term environmental challenges, however, genetic adaptation of the nucleosome code might lead to a converged epigenetic state, translating short-term adaptation into evolutionary adaptation. This is supported by the observation that the relevant nucleosome codes in the genomes of yeast species reflect their phylogenetic relationships.",
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Implications of the nucleosome code in regulatory variation, adaptation and evolution. / Choi, Jung Kyoon; Kim, Young Joon.

In: Epigenetics : official journal of the DNA Methylation Society, Vol. 4, No. 5, 01.07.2009, p. 291-295.

Research output: Contribution to journalReview article

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