Abstract
Despite its importance in transcriptional regulation, only recently has epigenetics attracted attention in the research of genomic expression variation and evolution. Recent studies suggested that positioned nucleosomes in a specific region of the promoter are associated with regulatory variation, regardless of being stochastic, environmental, genetic or evolutionary. Further, this intrinsically variable transcriptional pattern was proposed to be hardwired in the underlying promoter sequences that govern nucleosome organization. It seems that this nucleosome code for intrinsic variation is essential in the regulatory control of stress response. Stochastic remodeling of cis-encoded nucleosomes could provide transcriptional plasticity and resilience to transient environmental stresses. In response to long-term environmental challenges, however, genetic adaptation of the nucleosome code might lead to a converged epigenetic state, translating short-term adaptation into evolutionary adaptation. This is supported by the observation that the relevant nucleosome codes in the genomes of yeast species reflect their phylogenetic relationships.
| Original language | English |
|---|---|
| Pages (from-to) | 291-295 |
| Number of pages | 5 |
| Journal | Epigenetics : official journal of the DNA Methylation Society |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2009 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cancer Research
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Implications of the nucleosome code in regulatory variation, adaptation and evolution. / Choi, Jung Kyoon; Kim, Young Joon.
In: Epigenetics : official journal of the DNA Methylation Society, Vol. 4, No. 5, 01.07.2009, p. 291-295.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Implications of the nucleosome code in regulatory variation, adaptation and evolution.
AU - Choi, Jung Kyoon
AU - Kim, Young Joon
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Despite its importance in transcriptional regulation, only recently has epigenetics attracted attention in the research of genomic expression variation and evolution. Recent studies suggested that positioned nucleosomes in a specific region of the promoter are associated with regulatory variation, regardless of being stochastic, environmental, genetic or evolutionary. Further, this intrinsically variable transcriptional pattern was proposed to be hardwired in the underlying promoter sequences that govern nucleosome organization. It seems that this nucleosome code for intrinsic variation is essential in the regulatory control of stress response. Stochastic remodeling of cis-encoded nucleosomes could provide transcriptional plasticity and resilience to transient environmental stresses. In response to long-term environmental challenges, however, genetic adaptation of the nucleosome code might lead to a converged epigenetic state, translating short-term adaptation into evolutionary adaptation. This is supported by the observation that the relevant nucleosome codes in the genomes of yeast species reflect their phylogenetic relationships.
AB - Despite its importance in transcriptional regulation, only recently has epigenetics attracted attention in the research of genomic expression variation and evolution. Recent studies suggested that positioned nucleosomes in a specific region of the promoter are associated with regulatory variation, regardless of being stochastic, environmental, genetic or evolutionary. Further, this intrinsically variable transcriptional pattern was proposed to be hardwired in the underlying promoter sequences that govern nucleosome organization. It seems that this nucleosome code for intrinsic variation is essential in the regulatory control of stress response. Stochastic remodeling of cis-encoded nucleosomes could provide transcriptional plasticity and resilience to transient environmental stresses. In response to long-term environmental challenges, however, genetic adaptation of the nucleosome code might lead to a converged epigenetic state, translating short-term adaptation into evolutionary adaptation. This is supported by the observation that the relevant nucleosome codes in the genomes of yeast species reflect their phylogenetic relationships.
UR - http://www.scopus.com/inward/record.url?scp=79956309239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956309239&partnerID=8YFLogxK
U2 - 10.4161/epi.4.5.9281
DO - 10.4161/epi.4.5.9281
M3 - Review article
C2 - 19597338
AN - SCOPUS:79956309239
VL - 4
SP - 291
EP - 295
JO - Epigenetics
JF - Epigenetics
SN - 1559-2294
IS - 5
ER -