Improvement in particle separation by hollow fiber flow field-flow fractionation and the potential use in obtaining particle size distribution

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Abstract

Particle separation in hollow fiber flow field-flow fractionation (HF- FIFFF) has been greatly improved by experimentation. Flow optimization and the use of an appropriate carrier solution allow for separation of particles by HF-FIFFF to reach nearly the level of separation efficiency normally achieved by a conventional flow FFF system. The retention ratio in HF-FIFFF is confirmed to R ≃ 4λ for a highly retained component. The effect of focusing/relaxation point and the theoretical considerations of particle retention in HF-FIFFF through experimentation are discussed. The current work attempts to measure the particle size distribution of a laboratory-prepared polydisperse polystyrene latex sample, and the resulting size distribution, show a reasonable agreement with that obtained by capillary hydrodynamic fractionation. The efforts made in this work could provide possibilities for an HF-FIFFF system that can be developed into a system using a disposable and inexpensive fiber (channel in flow FFF).

Original languageEnglish
Pages (from-to)3446-3452
Number of pages7
JournalAnalytical Chemistry
Volume71
Issue number16
DOIs
Publication statusPublished - 1999 Aug 15

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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