Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography

Jian Chen, Jae Ho Cheong, Jin Yun Mi, Junuk Kim, Seok Lim Joon, WooJin Hyung, H. N. Sung

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

BACKGROUND. Positron emission tomography (PET) with 18- fluorodeoxyglucose (FDG) has been used to both detect and stage a variety of malignancies. The current study examined the value of PET for preoperative staging of gastric adenocarcinoma. METHODS. Sixty-eight patients (49 males and 19 females) with gastric adenocarcinoma, who were referred for preoperative FDG-PET scans, were enrolled in this study. The patients underwent spiral-computed tomography (CT) within 1 week of referral. The final diagnosis in all patients was made by histologic and surgical findings. For quantitative PET analysis, the regional tumor FDG uptake was measured by the standardized uptake value (SUV). RESULTS. For the primary tumor of a gastric adenocarcinoma, PET demonstrated an increased uptake in 64 of 68 patients (sensitivity, 94%), with a mean SUV of 7.0 (range, 0.9-27.7). A comparison of FDG uptake and clinicopathologic features showed significant association between FDG uptake and macroscopic type, tumor size, lymph node metastasis, histologic type, and TNM stage. The PET scan had a similar accuracy with that of CT for diagnosing local and distant lymph node metastases as well as peritoneal status. In assessing local lymph node status, however, PET had a higher specificity than CT (92% vs. 62%, P = 0.000). Moreover, PET had additional diagnostic value in 10 (15%) of 68 patients by upstaging 4 (6%) and downstaging 6 (9%) patients. PET combined with CT was more accurate for preoperative staging than either modality alone (66% vs. 51%, 66% vs. 47%, respectively; P = 0.002). CONCLUSIONS. FDG-PET improves the preoperative TNM staging of gastric adenocarcinoma. Based on its superior specificity, FDG-PET can facilitate the selection of patients for a curative resection by confirming a nodal status identified by CT.

Original languageEnglish
Pages (from-to)2383-2390
Number of pages8
JournalCancer
Volume103
Issue number11
DOIs
Publication statusPublished - 2005 Jun 1

Fingerprint

Positron-Emission Tomography
Stomach
Adenocarcinoma
Tomography
Lymph Nodes
Neoplasms
Neoplasm Metastasis
Neoplasm Staging
Spiral Computed Tomography
Patient Selection
Referral and Consultation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chen, J., Cheong, J. H., Mi, J. Y., Kim, J., Joon, S. L., Hyung, W., & Sung, H. N. (2005). Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography. Cancer, 103(11), 2383-2390. https://doi.org/10.1002/cncr.21074
Chen, Jian ; Cheong, Jae Ho ; Mi, Jin Yun ; Kim, Junuk ; Joon, Seok Lim ; Hyung, WooJin ; Sung, H. N. / Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography. In: Cancer. 2005 ; Vol. 103, No. 11. pp. 2383-2390.
@article{e1be38cfa63a43c78c44bb62edc78bf6,
title = "Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography",
abstract = "BACKGROUND. Positron emission tomography (PET) with 18- fluorodeoxyglucose (FDG) has been used to both detect and stage a variety of malignancies. The current study examined the value of PET for preoperative staging of gastric adenocarcinoma. METHODS. Sixty-eight patients (49 males and 19 females) with gastric adenocarcinoma, who were referred for preoperative FDG-PET scans, were enrolled in this study. The patients underwent spiral-computed tomography (CT) within 1 week of referral. The final diagnosis in all patients was made by histologic and surgical findings. For quantitative PET analysis, the regional tumor FDG uptake was measured by the standardized uptake value (SUV). RESULTS. For the primary tumor of a gastric adenocarcinoma, PET demonstrated an increased uptake in 64 of 68 patients (sensitivity, 94{\%}), with a mean SUV of 7.0 (range, 0.9-27.7). A comparison of FDG uptake and clinicopathologic features showed significant association between FDG uptake and macroscopic type, tumor size, lymph node metastasis, histologic type, and TNM stage. The PET scan had a similar accuracy with that of CT for diagnosing local and distant lymph node metastases as well as peritoneal status. In assessing local lymph node status, however, PET had a higher specificity than CT (92{\%} vs. 62{\%}, P = 0.000). Moreover, PET had additional diagnostic value in 10 (15{\%}) of 68 patients by upstaging 4 (6{\%}) and downstaging 6 (9{\%}) patients. PET combined with CT was more accurate for preoperative staging than either modality alone (66{\%} vs. 51{\%}, 66{\%} vs. 47{\%}, respectively; P = 0.002). CONCLUSIONS. FDG-PET improves the preoperative TNM staging of gastric adenocarcinoma. Based on its superior specificity, FDG-PET can facilitate the selection of patients for a curative resection by confirming a nodal status identified by CT.",
author = "Jian Chen and Cheong, {Jae Ho} and Mi, {Jin Yun} and Junuk Kim and Joon, {Seok Lim} and WooJin Hyung and Sung, {H. N.}",
year = "2005",
month = "6",
day = "1",
doi = "10.1002/cncr.21074",
language = "English",
volume = "103",
pages = "2383--2390",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

Chen, J, Cheong, JH, Mi, JY, Kim, J, Joon, SL, Hyung, W & Sung, HN 2005, 'Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography', Cancer, vol. 103, no. 11, pp. 2383-2390. https://doi.org/10.1002/cncr.21074

Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography. / Chen, Jian; Cheong, Jae Ho; Mi, Jin Yun; Kim, Junuk; Joon, Seok Lim; Hyung, WooJin; Sung, H. N.

In: Cancer, Vol. 103, No. 11, 01.06.2005, p. 2383-2390.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improvement in preoperative staging of gastric adenocarcinoma with positron emission tomography

AU - Chen, Jian

AU - Cheong, Jae Ho

AU - Mi, Jin Yun

AU - Kim, Junuk

AU - Joon, Seok Lim

AU - Hyung, WooJin

AU - Sung, H. N.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - BACKGROUND. Positron emission tomography (PET) with 18- fluorodeoxyglucose (FDG) has been used to both detect and stage a variety of malignancies. The current study examined the value of PET for preoperative staging of gastric adenocarcinoma. METHODS. Sixty-eight patients (49 males and 19 females) with gastric adenocarcinoma, who were referred for preoperative FDG-PET scans, were enrolled in this study. The patients underwent spiral-computed tomography (CT) within 1 week of referral. The final diagnosis in all patients was made by histologic and surgical findings. For quantitative PET analysis, the regional tumor FDG uptake was measured by the standardized uptake value (SUV). RESULTS. For the primary tumor of a gastric adenocarcinoma, PET demonstrated an increased uptake in 64 of 68 patients (sensitivity, 94%), with a mean SUV of 7.0 (range, 0.9-27.7). A comparison of FDG uptake and clinicopathologic features showed significant association between FDG uptake and macroscopic type, tumor size, lymph node metastasis, histologic type, and TNM stage. The PET scan had a similar accuracy with that of CT for diagnosing local and distant lymph node metastases as well as peritoneal status. In assessing local lymph node status, however, PET had a higher specificity than CT (92% vs. 62%, P = 0.000). Moreover, PET had additional diagnostic value in 10 (15%) of 68 patients by upstaging 4 (6%) and downstaging 6 (9%) patients. PET combined with CT was more accurate for preoperative staging than either modality alone (66% vs. 51%, 66% vs. 47%, respectively; P = 0.002). CONCLUSIONS. FDG-PET improves the preoperative TNM staging of gastric adenocarcinoma. Based on its superior specificity, FDG-PET can facilitate the selection of patients for a curative resection by confirming a nodal status identified by CT.

AB - BACKGROUND. Positron emission tomography (PET) with 18- fluorodeoxyglucose (FDG) has been used to both detect and stage a variety of malignancies. The current study examined the value of PET for preoperative staging of gastric adenocarcinoma. METHODS. Sixty-eight patients (49 males and 19 females) with gastric adenocarcinoma, who were referred for preoperative FDG-PET scans, were enrolled in this study. The patients underwent spiral-computed tomography (CT) within 1 week of referral. The final diagnosis in all patients was made by histologic and surgical findings. For quantitative PET analysis, the regional tumor FDG uptake was measured by the standardized uptake value (SUV). RESULTS. For the primary tumor of a gastric adenocarcinoma, PET demonstrated an increased uptake in 64 of 68 patients (sensitivity, 94%), with a mean SUV of 7.0 (range, 0.9-27.7). A comparison of FDG uptake and clinicopathologic features showed significant association between FDG uptake and macroscopic type, tumor size, lymph node metastasis, histologic type, and TNM stage. The PET scan had a similar accuracy with that of CT for diagnosing local and distant lymph node metastases as well as peritoneal status. In assessing local lymph node status, however, PET had a higher specificity than CT (92% vs. 62%, P = 0.000). Moreover, PET had additional diagnostic value in 10 (15%) of 68 patients by upstaging 4 (6%) and downstaging 6 (9%) patients. PET combined with CT was more accurate for preoperative staging than either modality alone (66% vs. 51%, 66% vs. 47%, respectively; P = 0.002). CONCLUSIONS. FDG-PET improves the preoperative TNM staging of gastric adenocarcinoma. Based on its superior specificity, FDG-PET can facilitate the selection of patients for a curative resection by confirming a nodal status identified by CT.

UR - http://www.scopus.com/inward/record.url?scp=18844423748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18844423748&partnerID=8YFLogxK

U2 - 10.1002/cncr.21074

DO - 10.1002/cncr.21074

M3 - Article

VL - 103

SP - 2383

EP - 2390

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 11

ER -