In vitro activity of bedaquiline and delamanid against nontuberculous mycobacteria, including macrolide-resistant clinical isolates

Dae Hun Kim, Byung Woo Jhun, Seong Mi Moon, Su Young Kim, Kyeongman Jeon, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won Jung Koh

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Abstract

We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii. However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. kansasii. Bedaquiline also had low MIC values with macrolide-resistant NTM strains and warrants further investigation as a potential antibiotic for NTM treatment.

Original languageEnglish
Article numbere00665-19
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number8
DOIs
Publication statusPublished - 2019 Jan 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kim, D. H., Jhun, B. W., Moon, S. M., Kim, S. Y., Jeon, K., Kwon, O. J., Huh, H. J., Lee, N. Y., Shin, S. J., Daley, C. L., & Koh, W. J. (2019). In vitro activity of bedaquiline and delamanid against nontuberculous mycobacteria, including macrolide-resistant clinical isolates. Antimicrobial agents and chemotherapy, 63(8), [e00665-19]. https://doi.org/10.1128/AAC.00665-19