We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii. However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. kansasii. Bedaquiline also had low MIC values with macrolide-resistant NTM strains and warrants further investigation as a potential antibiotic for NTM treatment.
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF), funded by the South Korean Ministry of Science, Information, and Communications Technologies (grant NRF-2018R1A2A1A05018309 to W.-J.K.), and by the Basic Science Research Program through the NRF, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930738 to D.H.K.).
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases