In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria

Hosung Sohn, Kil Soo Lee, Young Kwan Ko, Jae Wook Ryu, Jae Choon Woo, Dong Wan Koo, SungJae Shin, Se Jin Ahn, A. Rum Shin, Chang Hwa Song, Eun Kyeong Jo, Jeong Kyu Park, Hwa Jung Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo. To develop AHAS inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against M. tuberculosis and non-tuberculous mycobacteria (NTM), and then evaluated for intracellular activity using mouse macrophages. Three new compounds with antimycobacterial activity comparable with that of SM were identified. These compounds exhibit significant activity against intracellular M. tuberculosis (including the drug-resistant M. tuberculosis strains), and NTM Mycobacterium abscessus and Mycobacterium kansasii, respectively.

Original languageEnglish
Pages (from-to)567-571
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume31
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

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Mycobacterium
Mycobacterium tuberculosis
Mycobacterium kansasii
Branched Chain Amino Acids
Multidrug-Resistant Tuberculosis
Biosynthetic Pathways
Macrophages
In Vitro Techniques
Enzymes
sulfometuron methyl

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Sohn, Hosung ; Lee, Kil Soo ; Ko, Young Kwan ; Ryu, Jae Wook ; Woo, Jae Choon ; Koo, Dong Wan ; Shin, SungJae ; Ahn, Se Jin ; Shin, A. Rum ; Song, Chang Hwa ; Jo, Eun Kyeong ; Park, Jeong Kyu ; Kim, Hwa Jung. / In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria. In: International Journal of Antimicrobial Agents. 2008 ; Vol. 31, No. 6. pp. 567-571.
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In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria. / Sohn, Hosung; Lee, Kil Soo; Ko, Young Kwan; Ryu, Jae Wook; Woo, Jae Choon; Koo, Dong Wan; Shin, SungJae; Ahn, Se Jin; Shin, A. Rum; Song, Chang Hwa; Jo, Eun Kyeong; Park, Jeong Kyu; Kim, Hwa Jung.

In: International Journal of Antimicrobial Agents, Vol. 31, No. 6, 01.06.2008, p. 567-571.

Research output: Contribution to journalArticle

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AU - Sohn, Hosung

AU - Lee, Kil Soo

AU - Ko, Young Kwan

AU - Ryu, Jae Wook

AU - Woo, Jae Choon

AU - Koo, Dong Wan

AU - Shin, SungJae

AU - Ahn, Se Jin

AU - Shin, A. Rum

AU - Song, Chang Hwa

AU - Jo, Eun Kyeong

AU - Park, Jeong Kyu

AU - Kim, Hwa Jung

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