In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria

Hosung Sohn; Kil Soo Lee; Young Kwan Ko; Jae Wook Ryu; Jae Choon Woo; Dong Wan Koo; Sung Jae Shin; Se Jin Ahn; A. Rum Shin; Chang Hwa Song; Eun Kyeong Jo; Jeong Kyu Park; Hwa Jung Kim

doi:10.1016/j.ijantimicag.2008.01.016

In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria

Hosung Sohn, Kil Soo Lee, Young Kwan Ko, Jae Wook Ryu, Jae Choon Woo, Dong Wan Koo, Sung Jae Shin, Se Jin Ahn, A. Rum Shin, Chang Hwa Song, Eun Kyeong Jo, Jeong Kyu Park, Hwa Jung Kim

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo. To develop AHAS inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against M. tuberculosis and non-tuberculous mycobacteria (NTM), and then evaluated for intracellular activity using mouse macrophages. Three new compounds with antimycobacterial activity comparable with that of SM were identified. These compounds exhibit significant activity against intracellular M. tuberculosis (including the drug-resistant M. tuberculosis strains), and NTM Mycobacterium abscessus and Mycobacterium kansasii, respectively.

Original language	English
Pages (from-to)	567-571
Number of pages	5
Journal	International Journal of Antimicrobial Agents
Volume	31
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2008.01.016
Publication status	Published - 2008 Jun

Bibliographical note

Funding Information:
Funding: This study was supported by a grant from the Korea Health 21 R&D project, Ministry of Health and Welfare, Republic of Korea (01-PJ10-PG6-01GM03-002) and a grant of the Korea Science & Engineering through the Infection Signaling Network Research Center (R13-2007-020-01000-0) at Chungnam National University.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2008.01.016

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Sohn, H., Lee, K. S., Ko, Y. K., Ryu, J. W., Woo, J. C., Koo, D. W., Shin, S. J., Ahn, S. J., Shin, A. R., Song, C. H., Jo, E. K., Park, J. K., & Kim, H. J. (2008). In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria. International Journal of Antimicrobial Agents, 31(6), 567-571. https://doi.org/10.1016/j.ijantimicag.2008.01.016

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title = "In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria",

abstract = "Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo. To develop AHAS inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against M. tuberculosis and non-tuberculous mycobacteria (NTM), and then evaluated for intracellular activity using mouse macrophages. Three new compounds with antimycobacterial activity comparable with that of SM were identified. These compounds exhibit significant activity against intracellular M. tuberculosis (including the drug-resistant M. tuberculosis strains), and NTM Mycobacterium abscessus and Mycobacterium kansasii, respectively.",

author = "Hosung Sohn and Lee, {Kil Soo} and Ko, {Young Kwan} and Ryu, {Jae Wook} and Woo, {Jae Choon} and Koo, {Dong Wan} and Shin, {Sung Jae} and Ahn, {Se Jin} and Shin, {A. Rum} and Song, {Chang Hwa} and Jo, {Eun Kyeong} and Park, {Jeong Kyu} and Kim, {Hwa Jung}",

note = "Funding Information: Funding: This study was supported by a grant from the Korea Health 21 R&D project, Ministry of Health and Welfare, Republic of Korea (01-PJ10-PG6-01GM03-002) and a grant of the Korea Science & Engineering through the Infection Signaling Network Research Center (R13-2007-020-01000-0) at Chungnam National University. ",

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Sohn, H, Lee, KS, Ko, YK, Ryu, JW, Woo, JC, Koo, DW, Shin, SJ, Ahn, SJ, Shin, AR, Song, CH, Jo, EK, Park, JK & Kim, HJ 2008, 'In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria', International Journal of Antimicrobial Agents, vol. 31, no. 6, pp. 567-571. https://doi.org/10.1016/j.ijantimicag.2008.01.016

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AU - Sohn, Hosung

AU - Lee, Kil Soo

AU - Ko, Young Kwan

AU - Ryu, Jae Wook

AU - Woo, Jae Choon

AU - Koo, Dong Wan

AU - Shin, Sung Jae

AU - Ahn, Se Jin

AU - Shin, A. Rum

AU - Song, Chang Hwa

AU - Jo, Eun Kyeong

AU - Park, Jeong Kyu

AU - Kim, Hwa Jung

N1 - Funding Information: Funding: This study was supported by a grant from the Korea Health 21 R&D project, Ministry of Health and Welfare, Republic of Korea (01-PJ10-PG6-01GM03-002) and a grant of the Korea Science & Engineering through the Infection Signaling Network Research Center (R13-2007-020-01000-0) at Chungnam National University.

PY - 2008/6

Y1 - 2008/6

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In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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