In vitro and in vivo anti-tumor effects of oriental herbal mixtures

Kye Won Park, Su hyang Ye, Young jun Kim, So Ra Jung, Min hyuk Bang, Han Woong Lee, Ki Moon Park

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

To identify antitumor materials, oriental herb extracts were investigated in the present study. The effects of individual oriental herb extracts (OHE) and a mixture of these extracts (MOHE) for antioxidant, free radical scavenging, and tumoricidal activities were determined. The OHEs and MOHE exhibited relatively high free radical scavenging and antioxidant activities, in a concentration dependent manner. The total phenolic contents of the extracts suggest that these compounds may have played a role, at least in part, in the free radical scavenging and antioxidant effects. Since the MOHE showed the highest toxicity against tumor cell lines, the MOHE was administrated in cancer mice models. Consistent with the in vitro studies, the MOHE resulted in prolonged life spans in cancer mice possibly by combination of its anticancer and antioxidant activities. Our data indicate the possibilities of using the MOHE to counteract carcinogenesis as well as other forms of electrophilic toxicity.

Original languageEnglish
Pages (from-to)1019-1027
Number of pages9
JournalFood Science and Biotechnology
Volume19
Issue number4
DOIs
Publication statusPublished - 2010 Aug

Bibliographical note

Funding Information:
Acknowledgments This work was supported by the Biogreen 21 Program (Code #20070301034009), Rural Development Administration, Korea. This work was also supported by Samsung Research Fund, Sungkyunkwan University, 2009.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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