In vitro and in vivo experimental effect of Korean red ginseng on erection

Youngdeuk Choi, KoonHo Rha, Hyung K.I. Choi

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Abstract

Purpose: To elucidate the efficacy of Korean red ginseng (KRG) on penile erectile tissue and erectile response, the effect of ginseng was evaluated in both in vivo and in vitro experiments in laboratory animals. Materials and Methods: Fifty milligrams of KRG per kilogram in weight was mixed in physiologic saline and given by mouth for 3 months to both rabbits and rats. In vitro experiments were performed by observing the responses to acetylcholine (ACh) and KRG of strips of rabbit corpus cavernosum. In vivo experiments were performed by measuring the cavernosal pressures after the stimulation of pelvic nerves innervating rat corpus cavernosum. Results: On rabbit cavernosal muscle strips precontracted with phenylephrine (5 x 10-6 M), increasing concentrations of ACh (10-7, 10-6, 10-5, 10-4 M) showed dose dependent relaxation in the control group (10-7 M: 15.32%, 10- 6 M: 35.44%, 10-5 M: 59.45%, 10-4 M: 76.54%)(p <0.01). After 3 months of KRG administration, the relaxation responses to ACh were increased significantly (10-7 M: 34.18%, 10-6 M: 56.35%, 10-5 M: 75.33%, 10-4 M: 89.86%)(p <0.01). Relaxation effects of KRG were significantly increased after administering KRG for 3 months, as evident by the intracavernousal pressure to electrostimulation being 107.52 cm. water in the control group and significantly increased to 138.34 cm. water after 3 months administration of KRG (p <0.01). Conclusion: We confirmed that the long-term administration of KRG enhances erectile capacity and that its action is mediated by endothelium-derived relaxing factor and peripheral neurophysiologic enhancement.

Original languageEnglish
Pages (from-to)1508-1511
Number of pages4
JournalJournal of Urology
Volume162
Issue number4
DOIs
Publication statusPublished - 1999 Jan 1

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Panax
Acetylcholine
Rabbits
In Vitro Techniques
Pressure
Endothelium-Dependent Relaxing Factors
Control Groups
Water
Laboratory Animals
Phenylephrine
Mouth
Weights and Measures
Muscles

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

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title = "In vitro and in vivo experimental effect of Korean red ginseng on erection",
abstract = "Purpose: To elucidate the efficacy of Korean red ginseng (KRG) on penile erectile tissue and erectile response, the effect of ginseng was evaluated in both in vivo and in vitro experiments in laboratory animals. Materials and Methods: Fifty milligrams of KRG per kilogram in weight was mixed in physiologic saline and given by mouth for 3 months to both rabbits and rats. In vitro experiments were performed by observing the responses to acetylcholine (ACh) and KRG of strips of rabbit corpus cavernosum. In vivo experiments were performed by measuring the cavernosal pressures after the stimulation of pelvic nerves innervating rat corpus cavernosum. Results: On rabbit cavernosal muscle strips precontracted with phenylephrine (5 x 10-6 M), increasing concentrations of ACh (10-7, 10-6, 10-5, 10-4 M) showed dose dependent relaxation in the control group (10-7 M: 15.32{\%}, 10- 6 M: 35.44{\%}, 10-5 M: 59.45{\%}, 10-4 M: 76.54{\%})(p <0.01). After 3 months of KRG administration, the relaxation responses to ACh were increased significantly (10-7 M: 34.18{\%}, 10-6 M: 56.35{\%}, 10-5 M: 75.33{\%}, 10-4 M: 89.86{\%})(p <0.01). Relaxation effects of KRG were significantly increased after administering KRG for 3 months, as evident by the intracavernousal pressure to electrostimulation being 107.52 cm. water in the control group and significantly increased to 138.34 cm. water after 3 months administration of KRG (p <0.01). Conclusion: We confirmed that the long-term administration of KRG enhances erectile capacity and that its action is mediated by endothelium-derived relaxing factor and peripheral neurophysiologic enhancement.",
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In vitro and in vivo experimental effect of Korean red ginseng on erection. / Choi, Youngdeuk; Rha, KoonHo; Choi, Hyung K.I.

In: Journal of Urology, Vol. 162, No. 4, 01.01.1999, p. 1508-1511.

Research output: Contribution to journalArticle

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N2 - Purpose: To elucidate the efficacy of Korean red ginseng (KRG) on penile erectile tissue and erectile response, the effect of ginseng was evaluated in both in vivo and in vitro experiments in laboratory animals. Materials and Methods: Fifty milligrams of KRG per kilogram in weight was mixed in physiologic saline and given by mouth for 3 months to both rabbits and rats. In vitro experiments were performed by observing the responses to acetylcholine (ACh) and KRG of strips of rabbit corpus cavernosum. In vivo experiments were performed by measuring the cavernosal pressures after the stimulation of pelvic nerves innervating rat corpus cavernosum. Results: On rabbit cavernosal muscle strips precontracted with phenylephrine (5 x 10-6 M), increasing concentrations of ACh (10-7, 10-6, 10-5, 10-4 M) showed dose dependent relaxation in the control group (10-7 M: 15.32%, 10- 6 M: 35.44%, 10-5 M: 59.45%, 10-4 M: 76.54%)(p <0.01). After 3 months of KRG administration, the relaxation responses to ACh were increased significantly (10-7 M: 34.18%, 10-6 M: 56.35%, 10-5 M: 75.33%, 10-4 M: 89.86%)(p <0.01). Relaxation effects of KRG were significantly increased after administering KRG for 3 months, as evident by the intracavernousal pressure to electrostimulation being 107.52 cm. water in the control group and significantly increased to 138.34 cm. water after 3 months administration of KRG (p <0.01). Conclusion: We confirmed that the long-term administration of KRG enhances erectile capacity and that its action is mediated by endothelium-derived relaxing factor and peripheral neurophysiologic enhancement.

AB - Purpose: To elucidate the efficacy of Korean red ginseng (KRG) on penile erectile tissue and erectile response, the effect of ginseng was evaluated in both in vivo and in vitro experiments in laboratory animals. Materials and Methods: Fifty milligrams of KRG per kilogram in weight was mixed in physiologic saline and given by mouth for 3 months to both rabbits and rats. In vitro experiments were performed by observing the responses to acetylcholine (ACh) and KRG of strips of rabbit corpus cavernosum. In vivo experiments were performed by measuring the cavernosal pressures after the stimulation of pelvic nerves innervating rat corpus cavernosum. Results: On rabbit cavernosal muscle strips precontracted with phenylephrine (5 x 10-6 M), increasing concentrations of ACh (10-7, 10-6, 10-5, 10-4 M) showed dose dependent relaxation in the control group (10-7 M: 15.32%, 10- 6 M: 35.44%, 10-5 M: 59.45%, 10-4 M: 76.54%)(p <0.01). After 3 months of KRG administration, the relaxation responses to ACh were increased significantly (10-7 M: 34.18%, 10-6 M: 56.35%, 10-5 M: 75.33%, 10-4 M: 89.86%)(p <0.01). Relaxation effects of KRG were significantly increased after administering KRG for 3 months, as evident by the intracavernousal pressure to electrostimulation being 107.52 cm. water in the control group and significantly increased to 138.34 cm. water after 3 months administration of KRG (p <0.01). Conclusion: We confirmed that the long-term administration of KRG enhances erectile capacity and that its action is mediated by endothelium-derived relaxing factor and peripheral neurophysiologic enhancement.

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