In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci

Jong Bae Kim, Gyu Sang Lee, Yun Bong Kim, Soo Kie Kim, Yong Hae Kim

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16 Citations (Scopus)

Abstract

The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC90 of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.

Original languageEnglish
Pages (from-to)613-615
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number6
DOIs
Publication statusPublished - 2004 Dec

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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