In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci

Jong Bae Kim, Gyu Sang Lee, Yun Bong Kim, Soo Kie Kim, Yong Hae Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC90 of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.

Original languageEnglish
Pages (from-to)613-615
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number6
DOIs
Publication statusPublished - 2004 Dec 1

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Echinomycin
Agar
Vancomycin-Resistant Enterococci
YK2000
In Vitro Techniques
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

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title = "In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci",
abstract = "The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC90 of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.",
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In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci. / Kim, Jong Bae; Lee, Gyu Sang; Kim, Yun Bong; Kim, Soo Kie; Kim, Yong Hae.

In: International Journal of Antimicrobial Agents, Vol. 24, No. 6, 01.12.2004, p. 613-615.

Research output: Contribution to journalArticle

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