In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines

Soo Kie Kim, Chan Mug Ahn, Tae Ue Kim, Sun Ju Choi, Yoon Sun Park, Woon Seob Shin, Choon Myung Koh

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C50H66N11S2). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalArchives of pharmacal research
Volume19
Issue number4
DOIs
Publication statusPublished - 1996 Aug

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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