In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

Kyung Ah Koo, Sang Hyun Sung, Jong Hee Park, Seung Hyun Kim, Ki Yong Lee, Young Choong Kim

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Ten phenylethanoid glycosides, forsythoside B, acteoside, 2′-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM.

Original languageEnglish
Pages (from-to)778-780
Number of pages3
JournalPlanta Medica
Volume71
Issue number8
DOIs
Publication statusPublished - 2005 Aug 1

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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