In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer

Jae Joon Jung, Hei Cheul Jeung, Hyun Cheol Chung, Jung Ok Lee, Tae Soo Kim, Yong Tai Kim, Sung Hoon Noh, Sun Young Rha

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gastric cancer is one of the most common cancers worldwide, and there are clinical caveats in predicting tumor response to chemotherapy. This study describes the construction of an in vitro pharmacogenomic database, and the selection of genes associated with chemosensitivity in gastric cancer cell lines. Gene expression and chemosensitivity databases were integrated using the Pearson correlation coefficient to give the GC-matrix. The 85 genes were selected that were commonly associated with chemosensitivity of the major anticancer drugs. We then focused on the genes that were highly correlated with each specific drug. Classification of cell lines based on the set of genes associated with each drug was consistent with the division into resistant or sensitive groups according to the chemosensitivity results. The GC-matrix of the gastric cancer cell line database was used to identify different sets of chemosensitivity-related genes for specific drugs or multiple drugs.

Original languageEnglish
Pages (from-to)52-61
Number of pages10
JournalGenomics
Volume93
Issue number1
DOIs
Publication statusPublished - 2009 Jan

All Science Journal Classification (ASJC) codes

  • Genetics

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