In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach

Xingshu Li, Sungsook Yu, Yoonji Lee, Tian Guo, Nahyun Kwon, Dayoung Lee, Su Cheong Yeom, Yejin Cho, Gyoungmi Kim, Jian Dong Huang, Sun Choi, KiTaek Nam, Juyoung Yoon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Albumin is a promising candidate as a biomarker for potential disease diagnostics and has been extensively used as a drug delivery carrier for decades. In these two directions, many albumin-detecting probes and exogenous albumin-based nanocomposite delivery systems have been developed. However, there are only a few cases demonstrating the specific interactions of exogenous probes with albumin in vivo, and nanocomposite delivery systems usually suffer from tedious fabrication processes and potential toxicity of the complexes. Herein, we demonstrate a facile "one-for-all" switchable nanotheranostic (NanoPcS) for both albumin detection and cancer treatment. In particular, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, is confirmed using an inducible transgenic mouse system. Fluorescence imaging and antitumor tests on different tumor models suggest that NanoPcS has superior tumor-targeting ability and the potential for time-modulated, activatable photodynamic therapy.

Original languageEnglish
Pages (from-to)1366-1372
Number of pages7
JournalJournal of the American Chemical Society
Volume141
Issue number3
DOIs
Publication statusPublished - 2019 Jan 23

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Photosensitizing Agents
Photosensitizers
Tumors
Albumins
Nanocomposites
Monomers
Photodynamic therapy
Oncology
Biomarkers
Drug delivery
Toxicity
Fluorescence
Imaging techniques
Fabrication
Neoplasms
Drug Carriers
Optical Imaging
Photochemotherapy
Transgenic Mice
phthalocyanine

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Li, Xingshu ; Yu, Sungsook ; Lee, Yoonji ; Guo, Tian ; Kwon, Nahyun ; Lee, Dayoung ; Yeom, Su Cheong ; Cho, Yejin ; Kim, Gyoungmi ; Huang, Jian Dong ; Choi, Sun ; Nam, KiTaek ; Yoon, Juyoung. / In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles : A Facile and Switchable Theranostic Approach. In: Journal of the American Chemical Society. 2019 ; Vol. 141, No. 3. pp. 1366-1372.
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In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles : A Facile and Switchable Theranostic Approach. / Li, Xingshu; Yu, Sungsook; Lee, Yoonji; Guo, Tian; Kwon, Nahyun; Lee, Dayoung; Yeom, Su Cheong; Cho, Yejin; Kim, Gyoungmi; Huang, Jian Dong; Choi, Sun; Nam, KiTaek; Yoon, Juyoung.

In: Journal of the American Chemical Society, Vol. 141, No. 3, 23.01.2019, p. 1366-1372.

Research output: Contribution to journalArticle

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AU - Li, Xingshu

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AU - Guo, Tian

AU - Kwon, Nahyun

AU - Lee, Dayoung

AU - Yeom, Su Cheong

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AU - Kim, Gyoungmi

AU - Huang, Jian Dong

AU - Choi, Sun

AU - Nam, KiTaek

AU - Yoon, Juyoung

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