In vivo antinociceptive antiinflamatory and antioxidative effects of the leaf and stem bark of Kalopanax pictus in rats

Hee Juhn Park, Jung Hwan Nam, Hyun Ju Jung, Won Bae Kim, Kwang Kyun Park, WonYoon Chung, Jongwon Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings: KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH extract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antinociceptive test was undertaken by acetic acid-induced writhing-, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS-1>KPS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical (OH) and Superoxide dismutase (SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume36
Issue number4
Publication statusPublished - 2005 Dec 1

Fingerprint

Kalopanax
Anti-Inflammatory Agents
Thiobarbituric Acid Reactive Substances
Carrageenan
Acetic Acid
Ecosystem
Lipofuscin
Functional Food
Capillary Permeability
Biocompatible Materials
Vegetables
Superoxide Dismutase
Tail
Edema
Rheumatoid Arthritis
Oxidative Stress
Pain
Liver

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Park, Hee Juhn ; Nam, Jung Hwan ; Jung, Hyun Ju ; Kim, Won Bae ; Park, Kwang Kyun ; Chung, WonYoon ; Choi, Jongwon. / In vivo antinociceptive antiinflamatory and antioxidative effects of the leaf and stem bark of Kalopanax pictus in rats. In: Korean Journal of Pharmacognosy. 2005 ; Vol. 36, No. 4. pp. 318-323.
@article{0e00ecef17fa4c0b85b1a8297c4fa6ff,
title = "In vivo antinociceptive antiinflamatory and antioxidative effects of the leaf and stem bark of Kalopanax pictus in rats",
abstract = "The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings: KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH extract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antinociceptive test was undertaken by acetic acid-induced writhing-, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS-1>KPS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical (OH) and Superoxide dismutase (SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.",
author = "Park, {Hee Juhn} and Nam, {Jung Hwan} and Jung, {Hyun Ju} and Kim, {Won Bae} and Park, {Kwang Kyun} and WonYoon Chung and Jongwon Choi",
year = "2005",
month = "12",
day = "1",
language = "English",
volume = "36",
pages = "318--323",
journal = "Korean Journal of Pharmacognosy",
issn = "0253-3073",
publisher = "Korean Society of Pharmacognosy",
number = "4",

}

In vivo antinociceptive antiinflamatory and antioxidative effects of the leaf and stem bark of Kalopanax pictus in rats. / Park, Hee Juhn; Nam, Jung Hwan; Jung, Hyun Ju; Kim, Won Bae; Park, Kwang Kyun; Chung, WonYoon; Choi, Jongwon.

In: Korean Journal of Pharmacognosy, Vol. 36, No. 4, 01.12.2005, p. 318-323.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vivo antinociceptive antiinflamatory and antioxidative effects of the leaf and stem bark of Kalopanax pictus in rats

AU - Park, Hee Juhn

AU - Nam, Jung Hwan

AU - Jung, Hyun Ju

AU - Kim, Won Bae

AU - Park, Kwang Kyun

AU - Chung, WonYoon

AU - Choi, Jongwon

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings: KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH extract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antinociceptive test was undertaken by acetic acid-induced writhing-, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS-1>KPS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical (OH) and Superoxide dismutase (SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.

AB - The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings: KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH extract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antinociceptive test was undertaken by acetic acid-induced writhing-, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS-1>KPS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical (OH) and Superoxide dismutase (SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.

UR - http://www.scopus.com/inward/record.url?scp=30444435197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30444435197&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 318

EP - 323

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

SN - 0253-3073

IS - 4

ER -