In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode

Ran A. Jeong, Jae Youn Hwang, Segyeong Joo, Taek Dong Chung, Sejin Park, Sun Kil Kang, Wonyong Lee, Hee Chan Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A new two-point calibration method for the subcutaneous amperometric continuous glucose sensor is reported. The proposed method is based on direct measurement of the background current (Io) using a non-enzyme electrode. For in vivo test, three electrodes were implanted in rabbits. Two of the three were identical needle-type enzyme electrodes with perfluorinated polymer outer layers (Pt/enzyme layer/Kel-F/PTFE/Kel-F/Nafion) that were placed in subcutaneous tissue and in a vessel (ear artery), respectively. And one non-enzyme electrode with exactly the same membrane composition as those of other two was in the subcutaneous layer to measure the background current. Implantation in the subcutaneous layer generated many crevices on the protecting layers of the electrodes. The signals from enzyme electrodes were effectively corrected by the measured background current from the non-enzyme electrode. In addition, a telemetric monitoring system was developed and evaluated for in vivo continuous glucose monitoring in order to alleviate the problems of motion artifact.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalBiosensors and Bioelectronics
Volume19
Issue number4
DOIs
Publication statusPublished - 2003 Dec 15

Fingerprint

Amperometric sensors
Glucose sensors
Calibration
Electrodes
Glucose
Enzyme electrodes
Biosensing Techniques
Implanted Electrodes
Subcutaneous Tissue
Polytetrafluoroethylene
Artifacts
Monitoring
Needles
Ear
Polymers
Polytetrafluoroethylenes
Arteries
Rabbits
Enzymes
Membranes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Jeong, R. A., Hwang, J. Y., Joo, S., Chung, T. D., Park, S., Kang, S. K., ... Kim, H. C. (2003). In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode. Biosensors and Bioelectronics, 19(4), 313-319. https://doi.org/10.1016/S0956-5663(03)00219-7
Jeong, Ran A. ; Hwang, Jae Youn ; Joo, Segyeong ; Chung, Taek Dong ; Park, Sejin ; Kang, Sun Kil ; Lee, Wonyong ; Kim, Hee Chan. / In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode. In: Biosensors and Bioelectronics. 2003 ; Vol. 19, No. 4. pp. 313-319.
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In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode. / Jeong, Ran A.; Hwang, Jae Youn; Joo, Segyeong; Chung, Taek Dong; Park, Sejin; Kang, Sun Kil; Lee, Wonyong; Kim, Hee Chan.

In: Biosensors and Bioelectronics, Vol. 19, No. 4, 15.12.2003, p. 313-319.

Research output: Contribution to journalArticle

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