In vivo characteristics of Korean Beijing Mycobacterium tuberculosis strain K1 in an aerosol challenge model and in the Cornell latent tuberculosis model

Bo Young Jeon, Jeongyeon Kwak, Mi Young Hahn, Seok Yong Eum, Jiyeon Yang, Seung Cheol Kim, Sang Nae Cho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The Beijing Mycobacterium tuberculosis family is widely distributed and is the most common M. tuberculosis strain in East Asia. The highly transmissible and predominant Beijing M. tuberculosis strain in Korea, M. tuberculosis K1, was characterized using an aerobic challenge mouse model and a latent tuberculosis model with M. tuberculosis H37Rv as a reference. M. tuberculosis K1 multiplied over ten times more rapidly than M. tuberculosis H37Rv during the early stage of infection and induced high levels of histopathology in the lung. Low levels of T helper cell (Th) Th1 [interferon (IFN)-γ, interleukin (IL)-12p40] and Th2 cytokines (IL-4, IL-10) were induced in the lungs of M. tuberculosis K1-infected mice. In the latent model, mice infected with M. tuberculosis K1 exhibited more frequent relapse from the latent state than did mice infected with M. tuberculosis H37Rv. In conclusion, M. tuberculosis K1, a prevalent Beijing strain in Korea, is expected to spread due to its rapid growth during the early stages of infection, low-level induction of the immune response and high relapse rates from a latent state.

Original languageEnglish
Pages (from-to)1373-1379
Number of pages7
JournalJournal of Medical Microbiology
Volume61
Issue numberPART 10
DOIs
Publication statusPublished - 2012 Oct 1

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Latent Tuberculosis
Aerosols
Mycobacterium tuberculosis
Korea
Beijing
Recurrence
Lung
Far East
Interleukins
Helper-Inducer T-Lymphocytes
Infection
Interleukin-4
Interleukin-10
Interferons

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Jeon, Bo Young ; Kwak, Jeongyeon ; Hahn, Mi Young ; Eum, Seok Yong ; Yang, Jiyeon ; Kim, Seung Cheol ; Cho, Sang Nae. / In vivo characteristics of Korean Beijing Mycobacterium tuberculosis strain K1 in an aerosol challenge model and in the Cornell latent tuberculosis model. In: Journal of Medical Microbiology. 2012 ; Vol. 61, No. PART 10. pp. 1373-1379.
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In vivo characteristics of Korean Beijing Mycobacterium tuberculosis strain K1 in an aerosol challenge model and in the Cornell latent tuberculosis model. / Jeon, Bo Young; Kwak, Jeongyeon; Hahn, Mi Young; Eum, Seok Yong; Yang, Jiyeon; Kim, Seung Cheol; Cho, Sang Nae.

In: Journal of Medical Microbiology, Vol. 61, No. PART 10, 01.10.2012, p. 1373-1379.

Research output: Contribution to journalArticle

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