In vivo comparison of multiple pulse and CW strategies for microbubble-enhanced ultrasound therapy

Binh C. Tran, Jongbum Seo, Timothy L. Hall, Zhen Xu, Kimberly Ives, J. Brian Fowlkes, Charles A. Cain

Research output: Contribution to journalConference article

5 Citations (Scopus)

Abstract

Stabilized microbubble (ultrasound contrast agent) introduction can effectively reduce the propagated energy required to produce tissue damage in vivo. Acoustic parameter adjustment can also produce therapeutic gains. We found that exposures containing multiple, short duration pulses produced more tissue damage than single, CW exposures of the same amplitude and propagated energy, both with and without contrast agent. We suspect the increased tissue damage resulted from the initiation of cavitation and maintenance of a highly dynamic microbubble population during insonation. Results suggest that active adjustment of acoustic parameters may make cavitation more controllable.

Original languageEnglish
Pages (from-to)909-912
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume1
Publication statusPublished - 2003 Dec 1
Event2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States
Duration: 2003 Oct 52003 Oct 8

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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