In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

Hanna Cho, Jae Yong Choi, Mi Song Hwang, You Jin Kim, Hye Mi Lee, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chulhyoung Lyoo

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Objective: To determine the in vivo cortical spreading pattern of tau and amyloid and to establish positron emission tomography (PET) image-based tau staging in the Alzheimer disease (AD) spectrum. Methods: We included 195 participants (53 AD, 52 amnestic mild cognitive impairment [MCI], 23 nonamnestic MCI, and 67 healthy controls) who underwent 2 PET scans (18F-florbetaben for amyloid-β and 18F-AV-1451 for tau). We assumed that regions with earlier appearances of pathology may show increased binding in a greater number of participants and acquired spreading order of tau accumulation by sorting the regional frequencies of involvement. We classified each participant into image-based tau stage based on the Z score of the composite region for each stage. Results: Tau accumulation was most frequently observed in the medial temporal regions and spread stepwise to the basal and lateral temporal, inferior parietal, posterior cingulate, and other association cortices, and then ultimately to the primary cortical regions. In contrast, amyloid accumulation was found with similar frequency in the diffuse neocortical areas and then finally spread to the medial temporal regions. The image-based tau stage correlated with the general cognitive status, whereas cortical thinning was found only in the advanced tau stages: medial temporal region in stage V and widespread cortex in stage VI. Interpretation: Our PET study replicated postmortem spreading patterns of tau and amyloid-β pathologies. Unlike the diffuse accumulation of amyloid throughout the neocortex, tau spreading occurred in a stepwise fashion through the networks. Image-based tau staging may be useful for the objective assessment of AD progression. Ann Neurol 2016;80:247–258.

Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalAnnals of Neurology
Volume80
Issue number2
DOIs
Publication statusPublished - 2016 Aug 1

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Amyloid
Alzheimer Disease
Temporal Lobe
Positron-Emission Tomography
Pathology
Neocortex
Gyrus Cinguli
Disease Progression
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Cho, Hanna ; Choi, Jae Yong ; Hwang, Mi Song ; Kim, You Jin ; Lee, Hye Mi ; Lee, Hye Sun ; Lee, Jae Hoon ; Ryu, Young Hoon ; Lee, Myung Sik ; Lyoo, Chulhyoung. / In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. In: Annals of Neurology. 2016 ; Vol. 80, No. 2. pp. 247-258.
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abstract = "Objective: To determine the in vivo cortical spreading pattern of tau and amyloid and to establish positron emission tomography (PET) image-based tau staging in the Alzheimer disease (AD) spectrum. Methods: We included 195 participants (53 AD, 52 amnestic mild cognitive impairment [MCI], 23 nonamnestic MCI, and 67 healthy controls) who underwent 2 PET scans (18F-florbetaben for amyloid-β and 18F-AV-1451 for tau). We assumed that regions with earlier appearances of pathology may show increased binding in a greater number of participants and acquired spreading order of tau accumulation by sorting the regional frequencies of involvement. We classified each participant into image-based tau stage based on the Z score of the composite region for each stage. Results: Tau accumulation was most frequently observed in the medial temporal regions and spread stepwise to the basal and lateral temporal, inferior parietal, posterior cingulate, and other association cortices, and then ultimately to the primary cortical regions. In contrast, amyloid accumulation was found with similar frequency in the diffuse neocortical areas and then finally spread to the medial temporal regions. The image-based tau stage correlated with the general cognitive status, whereas cortical thinning was found only in the advanced tau stages: medial temporal region in stage V and widespread cortex in stage VI. Interpretation: Our PET study replicated postmortem spreading patterns of tau and amyloid-β pathologies. Unlike the diffuse accumulation of amyloid throughout the neocortex, tau spreading occurred in a stepwise fashion through the networks. Image-based tau staging may be useful for the objective assessment of AD progression. Ann Neurol 2016;80:247–258.",
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Cho, H, Choi, JY, Hwang, MS, Kim, YJ, Lee, HM, Lee, HS, Lee, JH, Ryu, YH, Lee, MS & Lyoo, C 2016, 'In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum', Annals of Neurology, vol. 80, no. 2, pp. 247-258. https://doi.org/10.1002/ana.24711

In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. / Cho, Hanna; Choi, Jae Yong; Hwang, Mi Song; Kim, You Jin; Lee, Hye Mi; Lee, Hye Sun; Lee, Jae Hoon; Ryu, Young Hoon; Lee, Myung Sik; Lyoo, Chulhyoung.

In: Annals of Neurology, Vol. 80, No. 2, 01.08.2016, p. 247-258.

Research output: Contribution to journalArticle

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T1 - In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

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AU - Choi, Jae Yong

AU - Hwang, Mi Song

AU - Kim, You Jin

AU - Lee, Hye Mi

AU - Lee, Hye Sun

AU - Lee, Jae Hoon

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