In vivo-like microsystem for high contents anti-inflammatory drug screening

Kwang Lee, Hyungil Jung

Research output: Contribution to conferencePaper

Abstract

Microfluidic channels for the in vivo-like inflammatory system was fabricated. After confrim the expression of surface molecules in the microfluidic channel via immunocytochemistry, either activated or inhibited Jurkat T cells were perfused at 3 dyn/cm2 of shear stress into the device. The anti-inflammatory drug treated T cells showed the less binding to HUVECs, this indicated that our in vivo-like inflammatory microsystem can detect the binding difference among Jurkat T cells. Therefore, this system is useful for clinical diagnostics as well as high contents drug screening (HCS) on which pharmaceutical industry concentrates recently.

Original languageEnglish
Pages1597-1599
Number of pages3
Publication statusPublished - 2008 Jan 1
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period08/10/1208/10/16

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lee, K., & Jung, H. (2008). In vivo-like microsystem for high contents anti-inflammatory drug screening. 1597-1599. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.