In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals

Yong Min Huh, Young Wook Jun, Ho Taek Song, Sungjun Kim, Jin Sil Choi, Jae Hyun Lee, Sarah Yoon, Kyung Sup Kim, Jeon Soo Shin, Jin Suck Suh, Jinwoo Cheon

Research output: Contribution to journalArticle

763 Citations (Scopus)

Abstract

The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defined magnetic nanocrystal probe system with multiple capabilities, such as small size, strong magnetism, high biocompatibility, and the possession of active functionality for desired receptors. Our magnetic nanocrystals are conjugated to a cancer-targeting antibody, Herceptin, and subsequent utilization of these conjugates as MRI probes has been successfully demonstrated for the monitoring of in vivo selective targeting events of human cancer cells implanted in live mice. Further conjugation of these nanocrystal probes with fluorescent dye-labeled antibodies enables both in vitro and ex vivo optical detection of cancer as well as in vivo MRI, which are potentially applicable for an advanced multimodal detection system. Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.

Original languageEnglish
Pages (from-to)12387-12391
Number of pages5
JournalJournal of the American Chemical Society
Volume127
Issue number35
DOIs
Publication statusPublished - 2005 Sep 7

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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