In vivo multi-slice mapping of myelin water content using T2* decay

Dosik Hwang, Dong Hyun Kim, Yiping P. Du

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Quantitative assessment of the myelin water content in the brain can substantially improve our understanding of white matter diseases such as multiple sclerosis. In this study, in vivo myelin water content was estimated using T2 relaxation with multi-slice acquisitions in magnetic resonance imaging (MRI). The main advantages of using T2 relaxation are (1) a low specific absorption rate (SAR), which is especially beneficial for imaging at high field strengths, (2) a short first-echo time (~2ms) and short echo spacing (~1ms), which allows for the acquisition of multiple sampling points during the fast decay of the myelin water signal, and (3) fast multi-slice acquisitions. High-resolution and multi-slice myelin water fraction (MWF) maps were obtained in a clinically acceptable scan time at 3T. Five healthy adults were scanned with a multi-gradient-echo sequence to acquire T2 signal decay data. Images with a dimension of 256×256 at eight slice locations were acquired in 8.5min with a signal-to-noise ratio (SNR) of 94.8 in the first-echo images. The SNR was further increased by using an anisotropic diffusion filter. Local field gradients (LFG) were estimated from the acquired multi-slice data, and the LFG-induced signal decays were corrected with a first-order approximation of LFG using the sinc function. The corrected T2 signal decays were analyzed with a three-pool model to quantify MWF. Our results demonstrate the feasibility of in ivo multi-slice mapping of MWF using multi-compartmental analysis of the T2 signal decay.

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalNeuroImage
Volume52
Issue number1
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Myelin Sheath
Water
Signal-To-Noise Ratio
Leukoencephalopathies
Multiple Sclerosis
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

@article{4e019b5ad6c84e3bbe9f57c997a6f34c,
title = "In vivo multi-slice mapping of myelin water content using T2* decay",
abstract = "Quantitative assessment of the myelin water content in the brain can substantially improve our understanding of white matter diseases such as multiple sclerosis. In this study, in vivo myelin water content was estimated using T2 relaxation with multi-slice acquisitions in magnetic resonance imaging (MRI). The main advantages of using T2 relaxation are (1) a low specific absorption rate (SAR), which is especially beneficial for imaging at high field strengths, (2) a short first-echo time (~2ms) and short echo spacing (~1ms), which allows for the acquisition of multiple sampling points during the fast decay of the myelin water signal, and (3) fast multi-slice acquisitions. High-resolution and multi-slice myelin water fraction (MWF) maps were obtained in a clinically acceptable scan time at 3T. Five healthy adults were scanned with a multi-gradient-echo sequence to acquire T2 signal decay data. Images with a dimension of 256×256 at eight slice locations were acquired in 8.5min with a signal-to-noise ratio (SNR) of 94.8 in the first-echo images. The SNR was further increased by using an anisotropic diffusion filter. Local field gradients (LFG) were estimated from the acquired multi-slice data, and the LFG-induced signal decays were corrected with a first-order approximation of LFG using the sinc function. The corrected T2 signal decays were analyzed with a three-pool model to quantify MWF. Our results demonstrate the feasibility of in ivo multi-slice mapping of MWF using multi-compartmental analysis of the T2 signal decay.",
author = "Dosik Hwang and Kim, {Dong Hyun} and Du, {Yiping P.}",
year = "2010",
month = "8",
day = "1",
doi = "10.1016/j.neuroimage.2010.04.023",
language = "English",
volume = "52",
pages = "198--204",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "1",

}

In vivo multi-slice mapping of myelin water content using T2* decay. / Hwang, Dosik; Kim, Dong Hyun; Du, Yiping P.

In: NeuroImage, Vol. 52, No. 1, 01.08.2010, p. 198-204.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vivo multi-slice mapping of myelin water content using T2* decay

AU - Hwang, Dosik

AU - Kim, Dong Hyun

AU - Du, Yiping P.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Quantitative assessment of the myelin water content in the brain can substantially improve our understanding of white matter diseases such as multiple sclerosis. In this study, in vivo myelin water content was estimated using T2 relaxation with multi-slice acquisitions in magnetic resonance imaging (MRI). The main advantages of using T2 relaxation are (1) a low specific absorption rate (SAR), which is especially beneficial for imaging at high field strengths, (2) a short first-echo time (~2ms) and short echo spacing (~1ms), which allows for the acquisition of multiple sampling points during the fast decay of the myelin water signal, and (3) fast multi-slice acquisitions. High-resolution and multi-slice myelin water fraction (MWF) maps were obtained in a clinically acceptable scan time at 3T. Five healthy adults were scanned with a multi-gradient-echo sequence to acquire T2 signal decay data. Images with a dimension of 256×256 at eight slice locations were acquired in 8.5min with a signal-to-noise ratio (SNR) of 94.8 in the first-echo images. The SNR was further increased by using an anisotropic diffusion filter. Local field gradients (LFG) were estimated from the acquired multi-slice data, and the LFG-induced signal decays were corrected with a first-order approximation of LFG using the sinc function. The corrected T2 signal decays were analyzed with a three-pool model to quantify MWF. Our results demonstrate the feasibility of in ivo multi-slice mapping of MWF using multi-compartmental analysis of the T2 signal decay.

AB - Quantitative assessment of the myelin water content in the brain can substantially improve our understanding of white matter diseases such as multiple sclerosis. In this study, in vivo myelin water content was estimated using T2 relaxation with multi-slice acquisitions in magnetic resonance imaging (MRI). The main advantages of using T2 relaxation are (1) a low specific absorption rate (SAR), which is especially beneficial for imaging at high field strengths, (2) a short first-echo time (~2ms) and short echo spacing (~1ms), which allows for the acquisition of multiple sampling points during the fast decay of the myelin water signal, and (3) fast multi-slice acquisitions. High-resolution and multi-slice myelin water fraction (MWF) maps were obtained in a clinically acceptable scan time at 3T. Five healthy adults were scanned with a multi-gradient-echo sequence to acquire T2 signal decay data. Images with a dimension of 256×256 at eight slice locations were acquired in 8.5min with a signal-to-noise ratio (SNR) of 94.8 in the first-echo images. The SNR was further increased by using an anisotropic diffusion filter. Local field gradients (LFG) were estimated from the acquired multi-slice data, and the LFG-induced signal decays were corrected with a first-order approximation of LFG using the sinc function. The corrected T2 signal decays were analyzed with a three-pool model to quantify MWF. Our results demonstrate the feasibility of in ivo multi-slice mapping of MWF using multi-compartmental analysis of the T2 signal decay.

UR - http://www.scopus.com/inward/record.url?scp=77953286931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953286931&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2010.04.023

DO - 10.1016/j.neuroimage.2010.04.023

M3 - Article

C2 - 20398770

AN - SCOPUS:77953286931

VL - 52

SP - 198

EP - 204

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -