In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents

Mohammad Mehrmohammadi, Tae Hyun Shin, Min Qu, Pieter Kruizinga, Ryan L. Truby, Jae Hyun Lee, Jinwoo Cheon, Stanislav Y. Emelianov

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34 Citations (Scopus)

Abstract

Previously, pulsed magneto-motive ultrasound (pMMUS) imaging has been introduced as a contrast-agent-assisted ultrasound-based imaging modality capable of visualizing biological events at the cellular and molecular level. In pMMUS imaging, a high intensity pulsed magnetic field is used to excite cells or tissue labeled with magnetic nanoparticles. Then, ultrasound (US) imaging is used to monitor the mechanical response of the tissue to an externally applied magnetic field (i.e., tissue displacement). Signal to noise ratio (SNR) in pMMUS imaging can be improved by using superparamagnetic nanoparticles with larger saturation magnetization. Metal-doped magnetic nanoparticles with enhanced tunable nanomagnetism are suitable candidates to improve the SNR and, therefore, sensitivity of pMMUS imaging, which is essential for in vivo pMMUS imaging. In this study, we demonstrate the capability of pMMUS imaging to identify the presence and distribution of zinc-doped iron oxide nanoparticles in live nude mice bearing A431 (human epithelial carcinoma) xenograft tumors.

Original languageEnglish
Pages (from-to)11179-11186
Number of pages8
JournalNanoscale
Volume5
Issue number22
DOIs
Publication statusPublished - 2013 Nov 21

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Mehrmohammadi, M., Shin, T. H., Qu, M., Kruizinga, P., Truby, R. L., Lee, J. H., Cheon, J., & Emelianov, S. Y. (2013). In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents. Nanoscale, 5(22), 11179-11186. https://doi.org/10.1039/c3nr03669c