In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Wonkeun Song, Borum Suh, JunYong Choi, Seokhoon Jeong, Eun Hee Jeon, Young Ki Lee, Seong Geun Hong, Kyungwon Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

Original languageEnglish
Pages (from-to)447-449
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume65
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

meropenem
Carbapenems
Klebsiella pneumoniae
Porins
Plasmids
Pressure
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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abstract = "We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.",
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In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment. / Song, Wonkeun; Suh, Borum; Choi, JunYong; Jeong, Seokhoon; Jeon, Eun Hee; Lee, Young Ki; Hong, Seong Geun; Lee, Kyungwon.

In: Diagnostic Microbiology and Infectious Disease, Vol. 65, No. 4, 01.12.2009, p. 447-449.

Research output: Contribution to journalArticle

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AU - Suh, Borum

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AU - Jeong, Seokhoon

AU - Jeon, Eun Hee

AU - Lee, Young Ki

AU - Hong, Seong Geun

AU - Lee, Kyungwon

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