In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Wonkeun Song, Borum Suh, Jun Yong Choi, Seok Hoon Jeong, Eun Hee Jeon, Young Ki Lee, Seong Geun Hong, Kyungwon Lee

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23 Citations (Scopus)

Abstract

We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

Original languageEnglish
Pages (from-to)447-449
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume65
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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