Inactivated eyedrop influenza vaccine adjuvanted with poly(I:C) is safe and effective for inducing protective systemic and mucosal immunity

Agriculture & Biology

• influenza vaccines 93%
• polyinosinic-polycytidylic acid 89%
• mucosal immunity 88%
• inactivated vaccines 82%
• vaccines 54%
• vaccination 47%
• antigens 39%
• influenza 37%
• adjuvants 33%
• antibody formation 31%
• cholera toxin 26%
• mice 24%
• cytokines 19%
• immunity 18%
• safety testing 16%
• eyes 16%
• conjunctiva 14%
• efficacy testing 13%
• olfactory bulb 13%
• hemagglutinins 11%
• Influenza A virus 11%
• interleukin-6 11%
• inflammation 9%
• brain 7%
• cells 6%

Medicine & Life Sciences

• Poly I-C 80%
• Mucosal Immunity 78%
• Ophthalmic Solutions 74%
• Influenza Vaccines 72%
• Vaccines 47%
• Vaccination 33%
• Antigens 33%
• Human Influenza 29%
• Antibody Formation 28%
• Inactivated Vaccines 26%
• Cholera Toxin 24%
• Immunity 17%
• H1N1 Subtype Influenza A Virus 13%
• Cytokines 13%
• Eye 13%
• Conjunctiva 12%
• Olfactory Bulb 12%
• Messenger RNA 12%
• Hemagglutinins 11%
• Immunoglobulin A 9%
• Serum 9%
• Interleukin-6 8%
• Immunoglobulin G 7%
• Inflammation 6%
• Safety 6%
• Brain 5%

Chemical Compounds

• Poly(I:C) 100%
• Eye Drop 92%
• Protective 52%
• Adjuvant 47%
• Antigen 42%
• Anti Influenza 37%
• Toxin 24%
• Intranasal 20%
• Ocular 16%
• Lethal 15%
• Safety 10%
• Surface 8%