Incidence and clinical features of Clostridium difficile infection in Korea

A nationwide study

Y. S. Kim, D. S. Han, Y. H. Kim, W. H. Kim, J. S. Kim, H. S. Kim, H. S. Kim, Y. S. Park, H. J. Song, S. J. Shin, S. K. Yang, B. D. Ye, C. S. Eun, K. M. Lee, S. H. Lee, B. I. Jang, S. A. Jung, JaeHee Cheon, C. H. Choi, K. C. Huh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

SUMMARY The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P' =' 0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9%). Relapse rate was 8·9% and complicated CDI was only observed in 3·6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalEpidemiology and Infection
Volume141
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Clostridium Infections
Clostridium difficile
Korea
Incidence
Republic of Korea
Metronidazole
Epidemiology
Recurrence

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

Cite this

Kim, Y. S., Han, D. S., Kim, Y. H., Kim, W. H., Kim, J. S., Kim, H. S., ... Huh, K. C. (2013). Incidence and clinical features of Clostridium difficile infection in Korea: A nationwide study. Epidemiology and Infection, 141(1), 189-194. https://doi.org/10.1017/S0950268812000581
Kim, Y. S. ; Han, D. S. ; Kim, Y. H. ; Kim, W. H. ; Kim, J. S. ; Kim, H. S. ; Kim, H. S. ; Park, Y. S. ; Song, H. J. ; Shin, S. J. ; Yang, S. K. ; Ye, B. D. ; Eun, C. S. ; Lee, K. M. ; Lee, S. H. ; Jang, B. I. ; Jung, S. A. ; Cheon, JaeHee ; Choi, C. H. ; Huh, K. C. / Incidence and clinical features of Clostridium difficile infection in Korea : A nationwide study. In: Epidemiology and Infection. 2013 ; Vol. 141, No. 1. pp. 189-194.
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abstract = "SUMMARY The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P' =' 0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9{\%}). Relapse rate was 8·9{\%} and complicated CDI was only observed in 3·6{\%}. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.",
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Kim, YS, Han, DS, Kim, YH, Kim, WH, Kim, JS, Kim, HS, Kim, HS, Park, YS, Song, HJ, Shin, SJ, Yang, SK, Ye, BD, Eun, CS, Lee, KM, Lee, SH, Jang, BI, Jung, SA, Cheon, J, Choi, CH & Huh, KC 2013, 'Incidence and clinical features of Clostridium difficile infection in Korea: A nationwide study', Epidemiology and Infection, vol. 141, no. 1, pp. 189-194. https://doi.org/10.1017/S0950268812000581

Incidence and clinical features of Clostridium difficile infection in Korea : A nationwide study. / Kim, Y. S.; Han, D. S.; Kim, Y. H.; Kim, W. H.; Kim, J. S.; Kim, H. S.; Kim, H. S.; Park, Y. S.; Song, H. J.; Shin, S. J.; Yang, S. K.; Ye, B. D.; Eun, C. S.; Lee, K. M.; Lee, S. H.; Jang, B. I.; Jung, S. A.; Cheon, JaeHee; Choi, C. H.; Huh, K. C.

In: Epidemiology and Infection, Vol. 141, No. 1, 01.01.2013, p. 189-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence and clinical features of Clostridium difficile infection in Korea

T2 - A nationwide study

AU - Kim, Y. S.

AU - Han, D. S.

AU - Kim, Y. H.

AU - Kim, W. H.

AU - Kim, J. S.

AU - Kim, H. S.

AU - Kim, H. S.

AU - Park, Y. S.

AU - Song, H. J.

AU - Shin, S. J.

AU - Yang, S. K.

AU - Ye, B. D.

AU - Eun, C. S.

AU - Lee, K. M.

AU - Lee, S. H.

AU - Jang, B. I.

AU - Jung, S. A.

AU - Cheon, JaeHee

AU - Choi, C. H.

AU - Huh, K. C.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - SUMMARY The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P' =' 0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9%). Relapse rate was 8·9% and complicated CDI was only observed in 3·6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.

AB - SUMMARY The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P' =' 0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9%). Relapse rate was 8·9% and complicated CDI was only observed in 3·6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.

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U2 - 10.1017/S0950268812000581

DO - 10.1017/S0950268812000581

M3 - Article

VL - 141

SP - 189

EP - 194

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

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