Incidence and clinical outcomes of intestinal Behçet’s disease in Korea, 2011–2014: a nationwide population-based study

Minkyung Han, Yoon Suk Jung, Won Ho Kim, Jae Hee Cheon, Sohee Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Intestinal Behçet’s disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. Methods: We collected data on 365 patients diagnosed with intestinal BD from 2011 to 2014 using the Health Insurance Review and Assessment Services claims database. We analyzed the incidence and clinical outcomes, including cumulative rates of bowel resection, hospitalization, and medication use. Results: During the study period, the average annual incidence for intestinal BD was 0.18 per 105 population, and the proportion of cases with intestinal involvement was 3.9%. At 1 and 4 years after diagnosis, the cumulative rates of surgery were 5.0 and 10.9%, respectively, whereas those of hospitalization were 27.8 and 32.4%, respectively. The 1- and 4-year cumulative rates of requirements for medications were 39.8 and 49.1% for moderate- to high-dose corticosteroids, 33.6 and 42.1% for immunomodulators, and 3.5 and 6.8% for biologics, respectively. The cumulative probability of corticosteroid and immunomodulator use was higher in male than in female patients and in younger (<40 years) than in older (≥40 years) patients. However, there were no significant differences in the cumulative probabilities of surgery, hospitalization, and biologics use according to sex and age group. Conclusions: The incidence of intestinal BD in Korea is quite low and has been stable in recent years.

Original languageEnglish
Pages (from-to)920-928
Number of pages9
JournalJournal of Gastroenterology
Volume52
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Intestinal Diseases
Korea
Incidence
Population
Hospitalization
Immunologic Factors
Biological Products
Adrenal Cortex Hormones
Health Insurance
Age Groups
Databases

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

@article{fc3337c097af4b128356a164ddaa7557,
title = "Incidence and clinical outcomes of intestinal Beh{\cc}et’s disease in Korea, 2011–2014: a nationwide population-based study",
abstract = "Background: Intestinal Beh{\cc}et’s disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. Methods: We collected data on 365 patients diagnosed with intestinal BD from 2011 to 2014 using the Health Insurance Review and Assessment Services claims database. We analyzed the incidence and clinical outcomes, including cumulative rates of bowel resection, hospitalization, and medication use. Results: During the study period, the average annual incidence for intestinal BD was 0.18 per 105 population, and the proportion of cases with intestinal involvement was 3.9{\%}. At 1 and 4 years after diagnosis, the cumulative rates of surgery were 5.0 and 10.9{\%}, respectively, whereas those of hospitalization were 27.8 and 32.4{\%}, respectively. The 1- and 4-year cumulative rates of requirements for medications were 39.8 and 49.1{\%} for moderate- to high-dose corticosteroids, 33.6 and 42.1{\%} for immunomodulators, and 3.5 and 6.8{\%} for biologics, respectively. The cumulative probability of corticosteroid and immunomodulator use was higher in male than in female patients and in younger (<40 years) than in older (≥40 years) patients. However, there were no significant differences in the cumulative probabilities of surgery, hospitalization, and biologics use according to sex and age group. Conclusions: The incidence of intestinal BD in Korea is quite low and has been stable in recent years.",
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Incidence and clinical outcomes of intestinal Behçet’s disease in Korea, 2011–2014 : a nationwide population-based study. / Han, Minkyung; Jung, Yoon Suk; Kim, Won Ho; Cheon, Jae Hee; Park, Sohee.

In: Journal of Gastroenterology, Vol. 52, No. 8, 01.08.2017, p. 920-928.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence and clinical outcomes of intestinal Behçet’s disease in Korea, 2011–2014

T2 - a nationwide population-based study

AU - Han, Minkyung

AU - Jung, Yoon Suk

AU - Kim, Won Ho

AU - Cheon, Jae Hee

AU - Park, Sohee

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Intestinal Behçet’s disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. Methods: We collected data on 365 patients diagnosed with intestinal BD from 2011 to 2014 using the Health Insurance Review and Assessment Services claims database. We analyzed the incidence and clinical outcomes, including cumulative rates of bowel resection, hospitalization, and medication use. Results: During the study period, the average annual incidence for intestinal BD was 0.18 per 105 population, and the proportion of cases with intestinal involvement was 3.9%. At 1 and 4 years after diagnosis, the cumulative rates of surgery were 5.0 and 10.9%, respectively, whereas those of hospitalization were 27.8 and 32.4%, respectively. The 1- and 4-year cumulative rates of requirements for medications were 39.8 and 49.1% for moderate- to high-dose corticosteroids, 33.6 and 42.1% for immunomodulators, and 3.5 and 6.8% for biologics, respectively. The cumulative probability of corticosteroid and immunomodulator use was higher in male than in female patients and in younger (<40 years) than in older (≥40 years) patients. However, there were no significant differences in the cumulative probabilities of surgery, hospitalization, and biologics use according to sex and age group. Conclusions: The incidence of intestinal BD in Korea is quite low and has been stable in recent years.

AB - Background: Intestinal Behçet’s disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. Methods: We collected data on 365 patients diagnosed with intestinal BD from 2011 to 2014 using the Health Insurance Review and Assessment Services claims database. We analyzed the incidence and clinical outcomes, including cumulative rates of bowel resection, hospitalization, and medication use. Results: During the study period, the average annual incidence for intestinal BD was 0.18 per 105 population, and the proportion of cases with intestinal involvement was 3.9%. At 1 and 4 years after diagnosis, the cumulative rates of surgery were 5.0 and 10.9%, respectively, whereas those of hospitalization were 27.8 and 32.4%, respectively. The 1- and 4-year cumulative rates of requirements for medications were 39.8 and 49.1% for moderate- to high-dose corticosteroids, 33.6 and 42.1% for immunomodulators, and 3.5 and 6.8% for biologics, respectively. The cumulative probability of corticosteroid and immunomodulator use was higher in male than in female patients and in younger (<40 years) than in older (≥40 years) patients. However, there were no significant differences in the cumulative probabilities of surgery, hospitalization, and biologics use according to sex and age group. Conclusions: The incidence of intestinal BD in Korea is quite low and has been stable in recent years.

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