Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis

Seung Whan Lee, Seong Wook Park, Myeongki Hong, Young Hak Kim, Ki Hoon Han, Jun Kim, Jae Hyeong Park, Sung Joo Oh, Dae Hyuk Moon, Seung Jun Oh, Cheol Whan Lee, Jae Joong Kim, Seung Jung Park

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Abstract

Background: The long-term fate of patent irradiated segments at 6 months after β-radiation therapy has not been sufficiently evaluated. Methods: Two-year follow-up angiography was performed in 52 patients with patent irradiated segments at 6 months after β-radiation with a rhenium 188-mercaptoacetyltriglycine-filled balloon for diffuse in-stent restenosis. We evaluated late recurrence (LR) and its predictors after β-radiation. Results: Late recurrence at 2 years after radiation was observed in 10 (19.2%) of 52 patients. The minimal lumen diameter (MLD) progressively decreased, from 2.67 ± 0.44 mm at postprocedure to 2.42 ± 0.53 mm at 6 months to 2.09 ± 0.75 mm at 2 years (P = .001). In the 42 patients without LR, the MLD decreased from postprocedure (2.74 ± 0.43 mm) to 6 months (2.44 ± 0.54 mm; P = .006), but did not change between 6 months and 2 years (2.35 ± 0.49 mm, P = .13). In the LR group, the MLD was unchanged from postprocedure (2.33 ± 0.29 mm) to 6 months (2.30 ± 0.43 mm; P = .81), but decreased significantly between 6 months and 2 years (1.02 ± 0.75 mm, P = .001). Multivariate analysis identified postprocedural MLD as an independent predictor of LR (odds ratio 0.025, 95% CI 0.007-0.94, P = .04). Late target lesion revascularization was performed in 6 patients (11.5%) between 6 months and 2 years after radiation. Conclusion: Although LR after radiation was observed in some patients, irradiated segments remained stable for up to 2 years in most patients. Smaller postprocedural MLD, followed by delayed late loss between 6 months and 2 years, was associated with LR.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalAmerican heart journal
Volume151
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

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Stents
Radiotherapy
Recurrence
Incidence
Radiation
Angiography
Multivariate Analysis
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Seung Whan ; Park, Seong Wook ; Hong, Myeongki ; Kim, Young Hak ; Han, Ki Hoon ; Kim, Jun ; Park, Jae Hyeong ; Oh, Sung Joo ; Moon, Dae Hyuk ; Oh, Seung Jun ; Lee, Cheol Whan ; Kim, Jae Joong ; Park, Seung Jung. / Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis In: American heart journal. 2006 ; Vol. 151, No. 1. pp. 158-163.
@article{e9db5ee35a9c47b0bdbaca857452e14b,
title = "Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis",
abstract = "Background: The long-term fate of patent irradiated segments at 6 months after β-radiation therapy has not been sufficiently evaluated. Methods: Two-year follow-up angiography was performed in 52 patients with patent irradiated segments at 6 months after β-radiation with a rhenium 188-mercaptoacetyltriglycine-filled balloon for diffuse in-stent restenosis. We evaluated late recurrence (LR) and its predictors after β-radiation. Results: Late recurrence at 2 years after radiation was observed in 10 (19.2{\%}) of 52 patients. The minimal lumen diameter (MLD) progressively decreased, from 2.67 ± 0.44 mm at postprocedure to 2.42 ± 0.53 mm at 6 months to 2.09 ± 0.75 mm at 2 years (P = .001). In the 42 patients without LR, the MLD decreased from postprocedure (2.74 ± 0.43 mm) to 6 months (2.44 ± 0.54 mm; P = .006), but did not change between 6 months and 2 years (2.35 ± 0.49 mm, P = .13). In the LR group, the MLD was unchanged from postprocedure (2.33 ± 0.29 mm) to 6 months (2.30 ± 0.43 mm; P = .81), but decreased significantly between 6 months and 2 years (1.02 ± 0.75 mm, P = .001). Multivariate analysis identified postprocedural MLD as an independent predictor of LR (odds ratio 0.025, 95{\%} CI 0.007-0.94, P = .04). Late target lesion revascularization was performed in 6 patients (11.5{\%}) between 6 months and 2 years after radiation. Conclusion: Although LR after radiation was observed in some patients, irradiated segments remained stable for up to 2 years in most patients. Smaller postprocedural MLD, followed by delayed late loss between 6 months and 2 years, was associated with LR.",
author = "Lee, {Seung Whan} and Park, {Seong Wook} and Myeongki Hong and Kim, {Young Hak} and Han, {Ki Hoon} and Jun Kim and Park, {Jae Hyeong} and Oh, {Sung Joo} and Moon, {Dae Hyuk} and Oh, {Seung Jun} and Lee, {Cheol Whan} and Kim, {Jae Joong} and Park, {Seung Jung}",
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Lee, SW, Park, SW, Hong, M, Kim, YH, Han, KH, Kim, J, Park, JH, Oh, SJ, Moon, DH, Oh, SJ, Lee, CW, Kim, JJ & Park, SJ 2006, ' Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis ', American heart journal, vol. 151, no. 1, pp. 158-163. https://doi.org/10.1016/j.ahj.2005.02.011

Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis . / Lee, Seung Whan; Park, Seong Wook; Hong, Myeongki; Kim, Young Hak; Han, Ki Hoon; Kim, Jun; Park, Jae Hyeong; Oh, Sung Joo; Moon, Dae Hyuk; Oh, Seung Jun; Lee, Cheol Whan; Kim, Jae Joong; Park, Seung Jung.

In: American heart journal, Vol. 151, No. 1, 01.01.2006, p. 158-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence and predictors of late recurrence after β-radiation therapy with a 188 Re-MAG 3 -filled balloon for diffuse in-stent restenosis

AU - Lee, Seung Whan

AU - Park, Seong Wook

AU - Hong, Myeongki

AU - Kim, Young Hak

AU - Han, Ki Hoon

AU - Kim, Jun

AU - Park, Jae Hyeong

AU - Oh, Sung Joo

AU - Moon, Dae Hyuk

AU - Oh, Seung Jun

AU - Lee, Cheol Whan

AU - Kim, Jae Joong

AU - Park, Seung Jung

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background: The long-term fate of patent irradiated segments at 6 months after β-radiation therapy has not been sufficiently evaluated. Methods: Two-year follow-up angiography was performed in 52 patients with patent irradiated segments at 6 months after β-radiation with a rhenium 188-mercaptoacetyltriglycine-filled balloon for diffuse in-stent restenosis. We evaluated late recurrence (LR) and its predictors after β-radiation. Results: Late recurrence at 2 years after radiation was observed in 10 (19.2%) of 52 patients. The minimal lumen diameter (MLD) progressively decreased, from 2.67 ± 0.44 mm at postprocedure to 2.42 ± 0.53 mm at 6 months to 2.09 ± 0.75 mm at 2 years (P = .001). In the 42 patients without LR, the MLD decreased from postprocedure (2.74 ± 0.43 mm) to 6 months (2.44 ± 0.54 mm; P = .006), but did not change between 6 months and 2 years (2.35 ± 0.49 mm, P = .13). In the LR group, the MLD was unchanged from postprocedure (2.33 ± 0.29 mm) to 6 months (2.30 ± 0.43 mm; P = .81), but decreased significantly between 6 months and 2 years (1.02 ± 0.75 mm, P = .001). Multivariate analysis identified postprocedural MLD as an independent predictor of LR (odds ratio 0.025, 95% CI 0.007-0.94, P = .04). Late target lesion revascularization was performed in 6 patients (11.5%) between 6 months and 2 years after radiation. Conclusion: Although LR after radiation was observed in some patients, irradiated segments remained stable for up to 2 years in most patients. Smaller postprocedural MLD, followed by delayed late loss between 6 months and 2 years, was associated with LR.

AB - Background: The long-term fate of patent irradiated segments at 6 months after β-radiation therapy has not been sufficiently evaluated. Methods: Two-year follow-up angiography was performed in 52 patients with patent irradiated segments at 6 months after β-radiation with a rhenium 188-mercaptoacetyltriglycine-filled balloon for diffuse in-stent restenosis. We evaluated late recurrence (LR) and its predictors after β-radiation. Results: Late recurrence at 2 years after radiation was observed in 10 (19.2%) of 52 patients. The minimal lumen diameter (MLD) progressively decreased, from 2.67 ± 0.44 mm at postprocedure to 2.42 ± 0.53 mm at 6 months to 2.09 ± 0.75 mm at 2 years (P = .001). In the 42 patients without LR, the MLD decreased from postprocedure (2.74 ± 0.43 mm) to 6 months (2.44 ± 0.54 mm; P = .006), but did not change between 6 months and 2 years (2.35 ± 0.49 mm, P = .13). In the LR group, the MLD was unchanged from postprocedure (2.33 ± 0.29 mm) to 6 months (2.30 ± 0.43 mm; P = .81), but decreased significantly between 6 months and 2 years (1.02 ± 0.75 mm, P = .001). Multivariate analysis identified postprocedural MLD as an independent predictor of LR (odds ratio 0.025, 95% CI 0.007-0.94, P = .04). Late target lesion revascularization was performed in 6 patients (11.5%) between 6 months and 2 years after radiation. Conclusion: Although LR after radiation was observed in some patients, irradiated segments remained stable for up to 2 years in most patients. Smaller postprocedural MLD, followed by delayed late loss between 6 months and 2 years, was associated with LR.

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U2 - 10.1016/j.ahj.2005.02.011

DO - 10.1016/j.ahj.2005.02.011

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JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

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