Incidence of acute kidney injury after adrenalectomy in patients with primary aldosteronism

Jee Young Lee, Hyoungnae Kim, Hyung Woo Kim, Geun Woo Ryu, Yooju Nam, Seonyeong Lee, Young Su Joo, Sangmi Lee, Jung Tak Park, Seung Hyeok Han, Shin Wook Kang, Tae Hyun Yoo, Hae Ryong Yun

Research output: Contribution to journalArticle

Abstract

Background: Aldosterone-induced glomerular hyperfiltration can lead to masked preoperative renal dysfunction in primary aldosteronism(PA) patients. We evaluated whether PA patients had a higher prevalence of acute kidney injury (AKI) after unilateral adrenalectomy. In addition, we identified risk factors for AKI in these subjects. Methods: This retrospective study included 107 PA patients, and 186 pheochromocytoma patients as a control group, all of whom underwent adrenalectomy between January 2006 and November 2017 at Yonsei University Severance Hospital. The primary outcome was AKI within 48 hours after adrenalectomy. Univariate and multivariate logistic regression analyses were performed to identify predictors of AKI after adrenalectomy. Results: Overall incidence of AKI was 49/293 (16.7%). In PA patients, the incidence of AKI was 29/107 (27.1%). In contrast, incidence of AKI was 20/ 186 (10.7%) in pheochromocytoma patients. Univariate and multivariate logistic regression analysis both showed a higher risk of postoperative AKI in PA patients compared to pheochromocytoma patients. In addition, old age, diabetes, longer duration of hypertension, lower preoperative estimated glomerular filtration rate, high aldosterone-cortisol ratio (ACR) and lateralization index (LI) were identified as independent risk factors for postoperative AKI in PA patients after unilateral adrenalectomy. Conclusion: Incidence and risk of postoperative AKI were significantly higher in PA patients after surgical treatment. High ACR on the tumor side and high LI were associated with higher risk of AKI in PA patients compared to pheochromocytoma patients.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalElectrolyte and Blood Pressure
Volume17
Issue number2
DOIs
Publication statusPublished - 2019 Dec

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Lee, J. Y., Kim, H., Kim, H. W., Ryu, G. W., Nam, Y., Lee, S., Joo, Y. S., Lee, S., Park, J. T., Han, S. H., Kang, S. W., Yoo, T. H., & Yun, H. R. (2019). Incidence of acute kidney injury after adrenalectomy in patients with primary aldosteronism. Electrolyte and Blood Pressure, 17(2), 45-53. https://doi.org/10.5049/EBP.2019.17.2.45