Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database

Jin Young Ahn; David Boettiger; Sasisopin Kiertiburanakul; Tuti Parwati Merati; Bui Vu Huy; Wing Wai Wong; Rossana Ditangco; Man Po Lee; Shinichi Oka; Nicolas Durier; Jun Yong Choi; C. V. Mean; V. Saphonn; K. Vohith; F. J. Zhang; H. X. Zhao; N. Han; P. C.K. Li; W. Lam; Y. T. Chan; N. Kumarasamy; S. Saghayam; C. Ezhilarasi; S. Pujari; K. Joshi; S. Gaikwad; A. Chitalikar; D. N. Wirawan; F. Yuliana; E. Yunihastuti; D. Imran; A. Widhani; J. Tanuma; T. Nishijima; S. Na; J. M. Kim; B. L.H. Sim; Y. M. Gani; R. David; A. Kamarulzaman; S. F. Syed Omar; S. Ponnampalavanar; I. Azwa; E. Uy; R. Bantique; W. W. Ku; P. C. Wu; O. T. Ng; P. L. Lim; L. S. Lee; P. S. Ohnmar; P. Phanuphak; K. Ruxrungtham; A. Avihingsanon; P. Chusut; S. Sirivichayakul; S. Sungkanuparph; L. Chumla; N. Sanmeema; R. Chaiwarith; T. Sirisanthana; W. Kotarathititum; J. Praparattanapan; P. Kantipong; P. Kambua; W. Ratanasuwan; R. Sriondee; V. K. Nguyen; V. H. Bui; T. H.D. Nguyen; T. T. Pham; D. D. Cuong; H. L. Ha; A. H. Sohn; B. Petersen; D. A. Cooper; M. G. Law; A. Jiamsakul

doi:10.7448/IAS.19.1.20965

Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database

Jin Young Ahn, David Boettiger, Sasisopin Kiertiburanakul, Tuti Parwati Merati, Bui Vu Huy, Wing Wai Wong, Rossana Ditangco, Man Po Lee, Shinichi Oka, Nicolas Durier, Jun Yong Choi, C. V. Mean, V. Saphonn, K. Vohith, F. J. Zhang, H. X. Zhao, N. Han, P. C.K. Li, W. Lam, Y. T. ChanN. Kumarasamy, S. Saghayam, C. Ezhilarasi, S. Pujari, K. Joshi, S. Gaikwad, A. Chitalikar, D. N. Wirawan, F. Yuliana, E. Yunihastuti, D. Imran, A. Widhani, J. Tanuma, T. Nishijima, S. Na, J. M. Kim, B. L.H. Sim, Y. M. Gani, R. David, A. Kamarulzaman, S. F. Syed Omar, S. Ponnampalavanar, I. Azwa, E. Uy, R. Bantique, W. W. Ku, P. C. Wu, O. T. Ng, P. L. Lim, L. S. Lee, P. S. Ohnmar, P. Phanuphak, K. Ruxrungtham, A. Avihingsanon, P. Chusut, S. Sirivichayakul, S. Sungkanuparph, L. Chumla, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, W. Kotarathititum, J. Praparattanapan, P. Kantipong, P. Kambua, W. Ratanasuwan, R. Sriondee, V. K. Nguyen, V. H. Bui, T. H.D. Nguyen, T. T. Pham, D. D. Cuong, H. L. Ha, A. H. Sohn, B. Petersen, D. A. Cooper, M. G. Law, A. Jiamsakul

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.

Original language	English
Article number	20965
Journal	Journal of the International AIDS Society
Volume	19
Issue number	1
DOIs	https://doi.org/10.7448/IAS.19.1.20965
Publication status	Published - 2016

Bibliographical note

Funding Information:
The TREAT Asia HIV Observational Database is an initiative of TREAT Asia, a programme of amfAR, The Foundation for AIDS Research, with support from the US National Institutes of Health's National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Cancer Institute, as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; U01AI069907). TREAT Asia receives additional support from ViiV Healthcare. The Kirby Institute is funded by the Australian Government Department of Health and Ageing and is affiliated with the Faculty of Medicine, UNSW Australia (The University of New South Wales). JYC's involvement was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2005412), and BioNano Health-Guard Research Center, funded by the Ministry of Science, ICT, and Future Planning of Korea as a Global Frontier Project (Grant H-GUARD-2013M3A6B2078953). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the governments or institutions mentioned above.

Publisher Copyright:
Copyright © 2016 Ahn JY et al; licensee International AIDS Society.

All Science Journal Classification (ASJC) codes

Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7448/IAS.19.1.20965

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Ahn, J. Y., Boettiger, D., Kiertiburanakul, S., Merati, T. P., Huy, B. V., Wong, W. W., Ditangco, R., Lee, M. P., Oka, S., Durier, N., Choi, J. Y., Mean, C. V., Saphonn, V., Vohith, K., Zhang, F. J., Zhao, H. X., Han, N., Li, P. C. K., Lam, W., ... Jiamsakul, A. (2016). Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database. Journal of the International AIDS Society, 19(1), [20965]. https://doi.org/10.7448/IAS.19.1.20965

@article{0e12e8f1d1954a51a3b5094a456c2909,

title = "Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database",

abstract = "Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.",

author = "Ahn, {Jin Young} and David Boettiger and Sasisopin Kiertiburanakul and Merati, {Tuti Parwati} and Huy, {Bui Vu} and Wong, {Wing Wai} and Rossana Ditangco and Lee, {Man Po} and Shinichi Oka and Nicolas Durier and Choi, {Jun Yong} and Mean, {C. V.} and V. Saphonn and K. Vohith and Zhang, {F. J.} and Zhao, {H. X.} and N. Han and Li, {P. C.K.} and W. Lam and Chan, {Y. T.} and N. Kumarasamy and S. Saghayam and C. Ezhilarasi and S. Pujari and K. Joshi and S. Gaikwad and A. Chitalikar and Wirawan, {D. N.} and F. Yuliana and E. Yunihastuti and D. Imran and A. Widhani and J. Tanuma and T. Nishijima and S. Na and Kim, {J. M.} and Sim, {B. L.H.} and Gani, {Y. M.} and R. David and A. Kamarulzaman and {Syed Omar}, {S. F.} and S. Ponnampalavanar and I. Azwa and E. Uy and R. Bantique and Ku, {W. W.} and Wu, {P. C.} and Ng, {O. T.} and Lim, {P. L.} and Lee, {L. S.} and Ohnmar, {P. S.} and P. Phanuphak and K. Ruxrungtham and A. Avihingsanon and P. Chusut and S. Sirivichayakul and S. Sungkanuparph and L. Chumla and N. Sanmeema and R. Chaiwarith and T. Sirisanthana and W. Kotarathititum and J. Praparattanapan and P. Kantipong and P. Kambua and W. Ratanasuwan and R. Sriondee and Nguyen, {V. K.} and Bui, {V. H.} and Nguyen, {T. H.D.} and Pham, {T. T.} and Cuong, {D. D.} and Ha, {H. L.} and Sohn, {A. H.} and B. Petersen and Cooper, {D. A.} and Law, {M. G.} and A. Jiamsakul",

note = "Funding Information: The TREAT Asia HIV Observational Database is an initiative of TREAT Asia, a programme of amfAR, The Foundation for AIDS Research, with support from the US National Institutes of Health's National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Cancer Institute, as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; U01AI069907). TREAT Asia receives additional support from ViiV Healthcare. The Kirby Institute is funded by the Australian Government Department of Health and Ageing and is affiliated with the Faculty of Medicine, UNSW Australia (The University of New South Wales). JYC's involvement was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2005412), and BioNano Health-Guard Research Center, funded by the Ministry of Science, ICT, and Future Planning of Korea as a Global Frontier Project (Grant H-GUARD-2013M3A6B2078953). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the governments or institutions mentioned above. Publisher Copyright: Copyright {\textcopyright} 2016 Ahn JY et al; licensee International AIDS Society.",

year = "2016",

doi = "10.7448/IAS.19.1.20965",

language = "English",

volume = "19",

journal = "Journal of the International AIDS Society",

issn = "1758-2652",

publisher = "International AIDS Society",

number = "1",

}

Ahn, JY, Boettiger, D, Kiertiburanakul, S, Merati, TP, Huy, BV, Wong, WW, Ditangco, R, Lee, MP, Oka, S, Durier, N, Choi, JY, Mean, CV, Saphonn, V, Vohith, K, Zhang, FJ, Zhao, HX, Han, N, Li, PCK, Lam, W, Chan, YT, Kumarasamy, N, Saghayam, S, Ezhilarasi, C, Pujari, S, Joshi, K, Gaikwad, S, Chitalikar, A, Wirawan, DN, Yuliana, F, Yunihastuti, E, Imran, D, Widhani, A, Tanuma, J, Nishijima, T, Na, S, Kim, JM, Sim, BLH, Gani, YM, David, R, Kamarulzaman, A, Syed Omar, SF, Ponnampalavanar, S, Azwa, I, Uy, E, Bantique, R, Ku, WW, Wu, PC, Ng, OT, Lim, PL, Lee, LS, Ohnmar, PS, Phanuphak, P, Ruxrungtham, K, Avihingsanon, A, Chusut, P, Sirivichayakul, S, Sungkanuparph, S, Chumla, L, Sanmeema, N, Chaiwarith, R, Sirisanthana, T, Kotarathititum, W, Praparattanapan, J, Kantipong, P, Kambua, P, Ratanasuwan, W, Sriondee, R, Nguyen, VK, Bui, VH, Nguyen, THD, Pham, TT, Cuong, DD, Ha, HL, Sohn, AH, Petersen, B, Cooper, DA, Law, MG & Jiamsakul, A 2016, 'Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database', Journal of the International AIDS Society, vol. 19, no. 1, 20965. https://doi.org/10.7448/IAS.19.1.20965

TY - JOUR

T1 - Incidence of syphilis seroconversion among HIV-infected persons in Asia

T2 - Results from the TREAT Asia HIV Observational Database

AU - Ahn, Jin Young

AU - Boettiger, David

AU - Kiertiburanakul, Sasisopin

AU - Merati, Tuti Parwati

AU - Huy, Bui Vu

AU - Wong, Wing Wai

AU - Ditangco, Rossana

AU - Lee, Man Po

AU - Oka, Shinichi

AU - Durier, Nicolas

AU - Choi, Jun Yong

AU - Mean, C. V.

AU - Saphonn, V.

AU - Vohith, K.

AU - Zhang, F. J.

AU - Zhao, H. X.

AU - Han, N.

AU - Li, P. C.K.

AU - Lam, W.

AU - Chan, Y. T.

AU - Kumarasamy, N.

AU - Saghayam, S.

AU - Ezhilarasi, C.

AU - Pujari, S.

AU - Joshi, K.

AU - Gaikwad, S.

AU - Chitalikar, A.

AU - Wirawan, D. N.

AU - Yuliana, F.

AU - Yunihastuti, E.

AU - Imran, D.

AU - Widhani, A.

AU - Tanuma, J.

AU - Nishijima, T.

AU - Na, S.

AU - Kim, J. M.

AU - Sim, B. L.H.

AU - Gani, Y. M.

AU - David, R.

AU - Kamarulzaman, A.

AU - Syed Omar, S. F.

AU - Ponnampalavanar, S.

AU - Azwa, I.

AU - Uy, E.

AU - Bantique, R.

AU - Ku, W. W.

AU - Wu, P. C.

AU - Ng, O. T.

AU - Lim, P. L.

AU - Lee, L. S.

AU - Ohnmar, P. S.

AU - Phanuphak, P.

AU - Ruxrungtham, K.

AU - Avihingsanon, A.

AU - Chusut, P.

AU - Sirivichayakul, S.

AU - Sungkanuparph, S.

AU - Chumla, L.

AU - Sanmeema, N.

AU - Chaiwarith, R.

AU - Sirisanthana, T.

AU - Kotarathititum, W.

AU - Praparattanapan, J.

AU - Kantipong, P.

AU - Kambua, P.

AU - Ratanasuwan, W.

AU - Sriondee, R.

AU - Nguyen, V. K.

AU - Bui, V. H.

AU - Nguyen, T. H.D.

AU - Pham, T. T.

AU - Cuong, D. D.

AU - Ha, H. L.

AU - Sohn, A. H.

AU - Petersen, B.

AU - Cooper, D. A.

AU - Law, M. G.

AU - Jiamsakul, A.

N1 - Funding Information: The TREAT Asia HIV Observational Database is an initiative of TREAT Asia, a programme of amfAR, The Foundation for AIDS Research, with support from the US National Institutes of Health's National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Cancer Institute, as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; U01AI069907). TREAT Asia receives additional support from ViiV Healthcare. The Kirby Institute is funded by the Australian Government Department of Health and Ageing and is affiliated with the Faculty of Medicine, UNSW Australia (The University of New South Wales). JYC's involvement was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2005412), and BioNano Health-Guard Research Center, funded by the Ministry of Science, ICT, and Future Planning of Korea as a Global Frontier Project (Grant H-GUARD-2013M3A6B2078953). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the governments or institutions mentioned above. Publisher Copyright: Copyright © 2016 Ahn JY et al; licensee International AIDS Society.

PY - 2016

Y1 - 2016

N2 - Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.

AB - Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.

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DO - 10.7448/IAS.19.1.20965

M3 - Article

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AN - SCOPUS:85015897781

SN - 1758-2652

VL - 19

JO - Journal of the International AIDS Society

JF - Journal of the International AIDS Society

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M1 - 20965

ER -

Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database

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UN SDGs

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