Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure.

Jihoe Heo, Seo Hyun Kim, Kyung Yul Lee, Eun Hee Kim, Chong Kyu Chu, Jeong Mo Nam

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45 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS: Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS: MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.

Original languageEnglish
JournalStroke; a journal of cerebral circulation
Volume34
Issue number6
Publication statusPublished - 2003 Jan 1

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Matrix Metalloproteinase 9
Stroke
Thrombosis
Arteries
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Platelet Aggregation
Healthy Volunteers
Blood Platelets
Enzyme-Linked Immunosorbent Assay

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Heo, Jihoe ; Kim, Seo Hyun ; Lee, Kyung Yul ; Kim, Eun Hee ; Chu, Chong Kyu ; Nam, Jeong Mo. / Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure. In: Stroke; a journal of cerebral circulation. 2003 ; Vol. 34, No. 6.
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Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure. / Heo, Jihoe; Kim, Seo Hyun; Lee, Kyung Yul; Kim, Eun Hee; Chu, Chong Kyu; Nam, Jeong Mo.

In: Stroke; a journal of cerebral circulation, Vol. 34, No. 6, 01.01.2003.

Research output: Contribution to journalArticle

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T1 - Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure.

AU - Heo, Jihoe

AU - Kim, Seo Hyun

AU - Lee, Kyung Yul

AU - Kim, Eun Hee

AU - Chu, Chong Kyu

AU - Nam, Jeong Mo

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N2 - BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS: Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS: MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.

AB - BACKGROUND AND PURPOSE: Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS: Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. RESULTS: The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. CONCLUSIONS: MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.

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