Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. In Korea: Analysis of KONSAR study data from 2005 and 2007

Kyungwon Lee, Mi Ae Lee, Chae Hoon Lee, Jongwook Lee, Kyoung Ho Roh, Sunjoo Kim, Jin Ju Kim, Eunmi Koh, Dongeun Yong, Yunsop Chong

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007. Materials and Methods: Susceptibility data for 2005 and 2007 were collected from 37 and 41 hospitals, respectively, and from one commercial laboratory. Intermediate susceptibility was not included in the calculation of resistance rates. Results: Methicillin-resistant Staphylococcus aureus (MRSA) (64%), third-generation cephalosporin-resistant Klebsiella pneumoniae (29%), fluoroquinolone-resistant Escherichia coli (27%), Pseudomonas aeruginosa (33%), and Acinetobacter spp. (48%), and amikacin-resistant P. aeruginosa (19%) and Acinetobacter spp. (37%) were prevalent in hospitals in 2007. A gradual increase of vancomycin-resistant Enterococcus faecium and imipenem-resistant Acinetobacter spp. was observed. Higher incidences of thirdgeneration cephalosporin-resistant E. coli and K. pneumoniae and imipenemresistant P. aeruginosa were found in the commercial laboratory than in the hospitals. Conclusion: Methicillin-resistant S. aureus, third-generation cephalosporin- resistant K. pneumoniae, and fluoroquinolone-resistant E. coli, P. aeruginosa and Acinetobacter spp. remain prevalent in Korea, while the incidence of vancomycin-resistant E. faecium and imipenem-resistant Acinetobacter spp. has increased gradually. The higher prevalences of third-generation cephalosporinresistant E. coli and K. pneumoniae, and imipenem-resistant P. aeruginosa in the commercial laboratory are a new concern.

Original languageEnglish
Pages (from-to)901-911
Number of pages11
JournalYonsei medical journal
Volume51
Issue number6
DOIs
Publication statusPublished - 2010 Nov 1

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Acinetobacter
Ceftazidime
Imipenem
Fluoroquinolones
Klebsiella pneumoniae
Korea
Pseudomonas aeruginosa
Cephalosporins
Escherichia coli
Methicillin-Resistant Staphylococcus aureus
Enterococcus faecium
Hospital Laboratories
Amikacin
Incidence
Cross Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Kyungwon ; Lee, Mi Ae ; Lee, Chae Hoon ; Lee, Jongwook ; Roh, Kyoung Ho ; Kim, Sunjoo ; Kim, Jin Ju ; Koh, Eunmi ; Yong, Dongeun ; Chong, Yunsop. / Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. In Korea : Analysis of KONSAR study data from 2005 and 2007. In: Yonsei medical journal. 2010 ; Vol. 51, No. 6. pp. 901-911.
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abstract = "Purpose: Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007. Materials and Methods: Susceptibility data for 2005 and 2007 were collected from 37 and 41 hospitals, respectively, and from one commercial laboratory. Intermediate susceptibility was not included in the calculation of resistance rates. Results: Methicillin-resistant Staphylococcus aureus (MRSA) (64{\%}), third-generation cephalosporin-resistant Klebsiella pneumoniae (29{\%}), fluoroquinolone-resistant Escherichia coli (27{\%}), Pseudomonas aeruginosa (33{\%}), and Acinetobacter spp. (48{\%}), and amikacin-resistant P. aeruginosa (19{\%}) and Acinetobacter spp. (37{\%}) were prevalent in hospitals in 2007. A gradual increase of vancomycin-resistant Enterococcus faecium and imipenem-resistant Acinetobacter spp. was observed. Higher incidences of thirdgeneration cephalosporin-resistant E. coli and K. pneumoniae and imipenemresistant P. aeruginosa were found in the commercial laboratory than in the hospitals. Conclusion: Methicillin-resistant S. aureus, third-generation cephalosporin- resistant K. pneumoniae, and fluoroquinolone-resistant E. coli, P. aeruginosa and Acinetobacter spp. remain prevalent in Korea, while the incidence of vancomycin-resistant E. faecium and imipenem-resistant Acinetobacter spp. has increased gradually. The higher prevalences of third-generation cephalosporinresistant E. coli and K. pneumoniae, and imipenem-resistant P. aeruginosa in the commercial laboratory are a new concern.",
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Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. In Korea : Analysis of KONSAR study data from 2005 and 2007. / Lee, Kyungwon; Lee, Mi Ae; Lee, Chae Hoon; Lee, Jongwook; Roh, Kyoung Ho; Kim, Sunjoo; Kim, Jin Ju; Koh, Eunmi; Yong, Dongeun; Chong, Yunsop.

In: Yonsei medical journal, Vol. 51, No. 6, 01.11.2010, p. 901-911.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. In Korea

T2 - Analysis of KONSAR study data from 2005 and 2007

AU - Lee, Kyungwon

AU - Lee, Mi Ae

AU - Lee, Chae Hoon

AU - Lee, Jongwook

AU - Roh, Kyoung Ho

AU - Kim, Sunjoo

AU - Kim, Jin Ju

AU - Koh, Eunmi

AU - Yong, Dongeun

AU - Chong, Yunsop

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Purpose: Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007. Materials and Methods: Susceptibility data for 2005 and 2007 were collected from 37 and 41 hospitals, respectively, and from one commercial laboratory. Intermediate susceptibility was not included in the calculation of resistance rates. Results: Methicillin-resistant Staphylococcus aureus (MRSA) (64%), third-generation cephalosporin-resistant Klebsiella pneumoniae (29%), fluoroquinolone-resistant Escherichia coli (27%), Pseudomonas aeruginosa (33%), and Acinetobacter spp. (48%), and amikacin-resistant P. aeruginosa (19%) and Acinetobacter spp. (37%) were prevalent in hospitals in 2007. A gradual increase of vancomycin-resistant Enterococcus faecium and imipenem-resistant Acinetobacter spp. was observed. Higher incidences of thirdgeneration cephalosporin-resistant E. coli and K. pneumoniae and imipenemresistant P. aeruginosa were found in the commercial laboratory than in the hospitals. Conclusion: Methicillin-resistant S. aureus, third-generation cephalosporin- resistant K. pneumoniae, and fluoroquinolone-resistant E. coli, P. aeruginosa and Acinetobacter spp. remain prevalent in Korea, while the incidence of vancomycin-resistant E. faecium and imipenem-resistant Acinetobacter spp. has increased gradually. The higher prevalences of third-generation cephalosporinresistant E. coli and K. pneumoniae, and imipenem-resistant P. aeruginosa in the commercial laboratory are a new concern.

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