Aims: The present study investigated the association between fasting glucose and arterial stiffness in subjects with normal fasting glucose (NFG) and impaired fasting glucose (IFG). Methods: The study group consisted of 1043 subjects, including 683 subjects with NFG and 360 subjects with IFG (100 ≤ fasting glucose < 126 mg/dL). All subjects were evaluated for glucose, insulin, lipid profiles, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), 8-epi-prostaglandin F2α (8-epi-PGF 2α) and brachial-ankle pulse wave velocity (ba-PWV). Results: MDA (P < 0.001) and ba-PWV (P < 0.001) in the IFG group were higher than those in the NFG group after adjustment for sex, age, BMI, smoking and drinking, waist, blood pressure, serum lipid profiles. Ba-PWV in the IFG group was still higher than that in the NFG group after further adjustment for hs-CRP, MDA, 8-epi-PGF2α (P = 0.031). Through multiple linear regression analysis, ba-PWV was found to be independently and positively associated with fasting glucose, age, systolic blood pressure, triglyceride, hs-CRP and insulin and negatively associated with male:female ratio, BMI. Conclusion: Arterial stiffness was higher in the IFG group than in subjects with NFG even after adjustment for all confounding variables including hs-CRP and oxidative stress markers. In addition, fasting glucose and insulin were positively and independently associated with the ba-PWV in non-diabetic healthy adults.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation, Ministry of Education, Science and Technology (Mid-career Researcher Program: 2012-0005604 , M10642120002-06N4212-00210 , and 2012M3A9C4048762 ) Republic of Korea. None of the authors had any personal or financial conflicts of interest.
Financial support: Mid-career Researcher Program through National Research Foundation of Korea ( 2012-0005604 , M10642120002-06N4212-00210 , and 2012M3A9C4048762 ), Republic of Korea.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism