Increased arterial stiffness in subjects with impaired fasting glucose

Jean Kyung Paik, Minjoo Kim, Jung Hyun Kwak, Eun Kyung Lee, Sang Hyun Lee, Jong Ho Lee

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Abstract

Aims: The present study investigated the association between fasting glucose and arterial stiffness in subjects with normal fasting glucose (NFG) and impaired fasting glucose (IFG). Methods: The study group consisted of 1043 subjects, including 683 subjects with NFG and 360 subjects with IFG (100 ≤ fasting glucose < 126 mg/dL). All subjects were evaluated for glucose, insulin, lipid profiles, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), 8-epi-prostaglandin F (8-epi-PGF ) and brachial-ankle pulse wave velocity (ba-PWV). Results: MDA (P < 0.001) and ba-PWV (P < 0.001) in the IFG group were higher than those in the NFG group after adjustment for sex, age, BMI, smoking and drinking, waist, blood pressure, serum lipid profiles. Ba-PWV in the IFG group was still higher than that in the NFG group after further adjustment for hs-CRP, MDA, 8-epi-PGF (P = 0.031). Through multiple linear regression analysis, ba-PWV was found to be independently and positively associated with fasting glucose, age, systolic blood pressure, triglyceride, hs-CRP and insulin and negatively associated with male:female ratio, BMI. Conclusion: Arterial stiffness was higher in the IFG group than in subjects with NFG even after adjustment for all confounding variables including hs-CRP and oxidative stress markers. In addition, fasting glucose and insulin were positively and independently associated with the ba-PWV in non-diabetic healthy adults.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalJournal of Diabetes and its Complications
Volume27
Issue number3
DOIs
Publication statusPublished - 2013 May 1

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Vascular Stiffness
Fasting
Glucose
Pulse Wave Analysis
Ankle
C-Reactive Protein
Arm
Malondialdehyde
Dinoprost
Insulin
Blood Pressure
Lipids
Confounding Factors (Epidemiology)
Prostaglandins F

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Paik, Jean Kyung ; Kim, Minjoo ; Kwak, Jung Hyun ; Lee, Eun Kyung ; Lee, Sang Hyun ; Lee, Jong Ho. / Increased arterial stiffness in subjects with impaired fasting glucose. In: Journal of Diabetes and its Complications. 2013 ; Vol. 27, No. 3. pp. 224-228.
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Increased arterial stiffness in subjects with impaired fasting glucose. / Paik, Jean Kyung; Kim, Minjoo; Kwak, Jung Hyun; Lee, Eun Kyung; Lee, Sang Hyun; Lee, Jong Ho.

In: Journal of Diabetes and its Complications, Vol. 27, No. 3, 01.05.2013, p. 224-228.

Research output: Contribution to journalArticle

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AU - Kim, Minjoo

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N2 - Aims: The present study investigated the association between fasting glucose and arterial stiffness in subjects with normal fasting glucose (NFG) and impaired fasting glucose (IFG). Methods: The study group consisted of 1043 subjects, including 683 subjects with NFG and 360 subjects with IFG (100 ≤ fasting glucose < 126 mg/dL). All subjects were evaluated for glucose, insulin, lipid profiles, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), 8-epi-prostaglandin F2α (8-epi-PGF 2α) and brachial-ankle pulse wave velocity (ba-PWV). Results: MDA (P < 0.001) and ba-PWV (P < 0.001) in the IFG group were higher than those in the NFG group after adjustment for sex, age, BMI, smoking and drinking, waist, blood pressure, serum lipid profiles. Ba-PWV in the IFG group was still higher than that in the NFG group after further adjustment for hs-CRP, MDA, 8-epi-PGF2α (P = 0.031). Through multiple linear regression analysis, ba-PWV was found to be independently and positively associated with fasting glucose, age, systolic blood pressure, triglyceride, hs-CRP and insulin and negatively associated with male:female ratio, BMI. Conclusion: Arterial stiffness was higher in the IFG group than in subjects with NFG even after adjustment for all confounding variables including hs-CRP and oxidative stress markers. In addition, fasting glucose and insulin were positively and independently associated with the ba-PWV in non-diabetic healthy adults.

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