Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina - Basal coronary artery tone in patients with variant angina

Seung Jung Park, Seong Wook Park, Jae Joong Kim, Jae Kwan Song, Myeongki Hong, Duk Hyun Kang, Sang Sig Cheong, Cheol Whan Lee, Jong Koo Lee

Research output: Contribution to journalArticle

Abstract

In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine(Ach) and ergonovine(Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients(Group 1) with variant angina in whom spasm was provoked by the low doses of Ach(intracoronary 20ug) or Erg(intravenous 50ug) and 35 patients(Group 2) provoked by higher doses of Ach(intracoronary 100ug) or Erg(intravenous cumulative dose of 350ug), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2(44±17 vs 14±11 % and 26±14 vs 16±10 % respectively, P<0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups(Ach; 40±20 vs 26±11, 27± 12%:Erg; 37±18 vs 12±8, 13±10% respectively, P<0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Korean medical science
Volume11
Issue number1
DOIs
Publication statusPublished - 1996 Jan 1

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Ergonovine
Spasm
Acetylcholine
Coronary Vessels
Muscle Spasticity
Arteries
Control Groups
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Seung Jung ; Park, Seong Wook ; Kim, Jae Joong ; Song, Jae Kwan ; Hong, Myeongki ; Kang, Duk Hyun ; Cheong, Sang Sig ; Lee, Cheol Whan ; Lee, Jong Koo. / Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina - Basal coronary artery tone in patients with variant angina. In: Journal of Korean medical science. 1996 ; Vol. 11, No. 1. pp. 17-25.
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abstract = "In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine(Ach) and ergonovine(Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients(Group 1) with variant angina in whom spasm was provoked by the low doses of Ach(intracoronary 20ug) or Erg(intravenous 50ug) and 35 patients(Group 2) provoked by higher doses of Ach(intracoronary 100ug) or Erg(intravenous cumulative dose of 350ug), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2(44±17 vs 14±11 {\%} and 26±14 vs 16±10 {\%} respectively, P<0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups(Ach; 40±20 vs 26±11, 27± 12{\%}:Erg; 37±18 vs 12±8, 13±10{\%} respectively, P<0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm.",
author = "Park, {Seung Jung} and Park, {Seong Wook} and Kim, {Jae Joong} and Song, {Jae Kwan} and Myeongki Hong and Kang, {Duk Hyun} and Cheong, {Sang Sig} and Lee, {Cheol Whan} and Lee, {Jong Koo}",
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Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina - Basal coronary artery tone in patients with variant angina. / Park, Seung Jung; Park, Seong Wook; Kim, Jae Joong; Song, Jae Kwan; Hong, Myeongki; Kang, Duk Hyun; Cheong, Sang Sig; Lee, Cheol Whan; Lee, Jong Koo.

In: Journal of Korean medical science, Vol. 11, No. 1, 01.01.1996, p. 17-25.

Research output: Contribution to journalArticle

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T1 - Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina - Basal coronary artery tone in patients with variant angina

AU - Park, Seung Jung

AU - Park, Seong Wook

AU - Kim, Jae Joong

AU - Song, Jae Kwan

AU - Hong, Myeongki

AU - Kang, Duk Hyun

AU - Cheong, Sang Sig

AU - Lee, Cheol Whan

AU - Lee, Jong Koo

PY - 1996/1/1

Y1 - 1996/1/1

N2 - In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine(Ach) and ergonovine(Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients(Group 1) with variant angina in whom spasm was provoked by the low doses of Ach(intracoronary 20ug) or Erg(intravenous 50ug) and 35 patients(Group 2) provoked by higher doses of Ach(intracoronary 100ug) or Erg(intravenous cumulative dose of 350ug), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2(44±17 vs 14±11 % and 26±14 vs 16±10 % respectively, P<0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups(Ach; 40±20 vs 26±11, 27± 12%:Erg; 37±18 vs 12±8, 13±10% respectively, P<0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm.

AB - In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic and non-spastic sites. Thus, the purpose of this study was to assess the basal coronary artery tone and the responsiveness to acetylcholine(Ach) and ergonovine(Erg) in patients with variant angina. We compared the basal coronary artery tone and the constrictive responses to Ach and Erg between 31 patients(Group 1) with variant angina in whom spasm was provoked by the low doses of Ach(intracoronary 20ug) or Erg(intravenous 50ug) and 35 patients(Group 2) provoked by higher doses of Ach(intracoronary 100ug) or Erg(intravenous cumulative dose of 350ug), and 26 control subjects. Patients with variant angina in whom spasm was provoked by low doses of Ach or Erg, had a higher incidence of mixed disease, multi-vessel spasm and higher disease activity. The basal coronary artery tone at the spastic and nonspastic sites of spasm related artery was significantly more elevated in Group 1 than that in Group 2(44±17 vs 14±11 % and 26±14 vs 16±10 % respectively, P<0.05), but not in the nonspasm related artery, The magnitudes of vasoconstrictive responses to Ach and Erg at the nonspastic sites were also greater in Group 1 than those in Group 2 and the control groups(Ach; 40±20 vs 26±11, 27± 12%:Erg; 37±18 vs 12±8, 13±10% respectively, P<0.05). However, the basal coronary artery tone was not elevated at the spastic and nonspastic sites in Group 2 compared to the in control subjects. These findings suggest that the basal coronary artery tone is increased in patients with variant angina with higher disease activity at the spastic sites and nonspastic sites of the spasm-related artery, and this may be related to the occurrence of coronary artery spasm.

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