Increased CSF tau level is correlated with decreased lamina cribrosa thickness

Eun Ji Lee, Tae Woo Kim, Dae Seung Lee, Hyunjoong Kim, Young Ho Park, Jungeun Kim, Joon Woo Lee, Sang Yun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study was to investigate whether the previously proposed link between Alzheimer's disease (AD) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal CSF profiles and optic nerve head characteristics, focusing on the influence of CSF tau protein on the lamina cribrosa (LC) thickness (LCT). Methods: A total of 44 eyes from 18 patients with AD and 26 healthy subjects were subjected to enhanced-depth-imaging volume scanning of the optic nerve using spectral-domain optical coherence tomography. The B-scan images were constructed three-dimensionally using maximum intensity projection (MIP), and the LCT was measured at three locations (superior midperipheral, midhorizontal, and inferior midperipheral) using the thin-slab MIP images. CSF levels of amyloid β 1-42 peptide, (Aβ 1-42 ), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau 181P ) were measured from CSF samples of each subject. The relationship between the level of CSF proteins and the LCT was determined using linear regression and fractional polynomial analyses. Results: Univariate regression analysis revealed that higher CSF levels of T-tau (P = 0.004) and P-tau 181P (P = 0.027), as well as a smaller central corneal thickness (P = 0.032), were significantly associated with a smaller LCT. Multivariate analysis indicated that only CSF T-tau (P = 0.041) was significantly associated with the LCT. The relationship was well explained by both linear regression (R 2 = 0.179, P = 0.004) and fractional polynomial analysis (R 2 = 0.275, P = 0.001). When we performed an assessment by linear regression with an indicator, the relationship was significant both in the healthy and AD groups, with a stronger correlation found in the healthy group (regression coefficients = -1.098 vs. -0.280, P = 0.018). Conclusions: An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remains to be determined.

Original languageEnglish
Article number6
JournalAlzheimer's Research and Therapy
Volume8
Issue number1
DOIs
Publication statusPublished - 2016 Feb 8

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Alzheimer Disease
Linear Models
Optic Nerve
tau Proteins
Optic Disk
Optical Coherence Tomography
Threonine
Nerve Fibers
Amyloid
Healthy Volunteers
Multivariate Analysis
Regression Analysis
Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Lee, Eun Ji ; Kim, Tae Woo ; Lee, Dae Seung ; Kim, Hyunjoong ; Park, Young Ho ; Kim, Jungeun ; Lee, Joon Woo ; Kim, Sang Yun. / Increased CSF tau level is correlated with decreased lamina cribrosa thickness. In: Alzheimer's Research and Therapy. 2016 ; Vol. 8, No. 1.
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abstract = "Background: This study was to investigate whether the previously proposed link between Alzheimer's disease (AD) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal CSF profiles and optic nerve head characteristics, focusing on the influence of CSF tau protein on the lamina cribrosa (LC) thickness (LCT). Methods: A total of 44 eyes from 18 patients with AD and 26 healthy subjects were subjected to enhanced-depth-imaging volume scanning of the optic nerve using spectral-domain optical coherence tomography. The B-scan images were constructed three-dimensionally using maximum intensity projection (MIP), and the LCT was measured at three locations (superior midperipheral, midhorizontal, and inferior midperipheral) using the thin-slab MIP images. CSF levels of amyloid β 1-42 peptide, (Aβ 1-42 ), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau 181P ) were measured from CSF samples of each subject. The relationship between the level of CSF proteins and the LCT was determined using linear regression and fractional polynomial analyses. Results: Univariate regression analysis revealed that higher CSF levels of T-tau (P = 0.004) and P-tau 181P (P = 0.027), as well as a smaller central corneal thickness (P = 0.032), were significantly associated with a smaller LCT. Multivariate analysis indicated that only CSF T-tau (P = 0.041) was significantly associated with the LCT. The relationship was well explained by both linear regression (R 2 = 0.179, P = 0.004) and fractional polynomial analysis (R 2 = 0.275, P = 0.001). When we performed an assessment by linear regression with an indicator, the relationship was significant both in the healthy and AD groups, with a stronger correlation found in the healthy group (regression coefficients = -1.098 vs. -0.280, P = 0.018). Conclusions: An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remains to be determined.",
author = "Lee, {Eun Ji} and Kim, {Tae Woo} and Lee, {Dae Seung} and Hyunjoong Kim and Park, {Young Ho} and Jungeun Kim and Lee, {Joon Woo} and Kim, {Sang Yun}",
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Increased CSF tau level is correlated with decreased lamina cribrosa thickness. / Lee, Eun Ji; Kim, Tae Woo; Lee, Dae Seung; Kim, Hyunjoong; Park, Young Ho; Kim, Jungeun; Lee, Joon Woo; Kim, Sang Yun.

In: Alzheimer's Research and Therapy, Vol. 8, No. 1, 6, 08.02.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased CSF tau level is correlated with decreased lamina cribrosa thickness

AU - Lee, Eun Ji

AU - Kim, Tae Woo

AU - Lee, Dae Seung

AU - Kim, Hyunjoong

AU - Park, Young Ho

AU - Kim, Jungeun

AU - Lee, Joon Woo

AU - Kim, Sang Yun

PY - 2016/2/8

Y1 - 2016/2/8

N2 - Background: This study was to investigate whether the previously proposed link between Alzheimer's disease (AD) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal CSF profiles and optic nerve head characteristics, focusing on the influence of CSF tau protein on the lamina cribrosa (LC) thickness (LCT). Methods: A total of 44 eyes from 18 patients with AD and 26 healthy subjects were subjected to enhanced-depth-imaging volume scanning of the optic nerve using spectral-domain optical coherence tomography. The B-scan images were constructed three-dimensionally using maximum intensity projection (MIP), and the LCT was measured at three locations (superior midperipheral, midhorizontal, and inferior midperipheral) using the thin-slab MIP images. CSF levels of amyloid β 1-42 peptide, (Aβ 1-42 ), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau 181P ) were measured from CSF samples of each subject. The relationship between the level of CSF proteins and the LCT was determined using linear regression and fractional polynomial analyses. Results: Univariate regression analysis revealed that higher CSF levels of T-tau (P = 0.004) and P-tau 181P (P = 0.027), as well as a smaller central corneal thickness (P = 0.032), were significantly associated with a smaller LCT. Multivariate analysis indicated that only CSF T-tau (P = 0.041) was significantly associated with the LCT. The relationship was well explained by both linear regression (R 2 = 0.179, P = 0.004) and fractional polynomial analysis (R 2 = 0.275, P = 0.001). When we performed an assessment by linear regression with an indicator, the relationship was significant both in the healthy and AD groups, with a stronger correlation found in the healthy group (regression coefficients = -1.098 vs. -0.280, P = 0.018). Conclusions: An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remains to be determined.

AB - Background: This study was to investigate whether the previously proposed link between Alzheimer's disease (AD) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal CSF profiles and optic nerve head characteristics, focusing on the influence of CSF tau protein on the lamina cribrosa (LC) thickness (LCT). Methods: A total of 44 eyes from 18 patients with AD and 26 healthy subjects were subjected to enhanced-depth-imaging volume scanning of the optic nerve using spectral-domain optical coherence tomography. The B-scan images were constructed three-dimensionally using maximum intensity projection (MIP), and the LCT was measured at three locations (superior midperipheral, midhorizontal, and inferior midperipheral) using the thin-slab MIP images. CSF levels of amyloid β 1-42 peptide, (Aβ 1-42 ), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau 181P ) were measured from CSF samples of each subject. The relationship between the level of CSF proteins and the LCT was determined using linear regression and fractional polynomial analyses. Results: Univariate regression analysis revealed that higher CSF levels of T-tau (P = 0.004) and P-tau 181P (P = 0.027), as well as a smaller central corneal thickness (P = 0.032), were significantly associated with a smaller LCT. Multivariate analysis indicated that only CSF T-tau (P = 0.041) was significantly associated with the LCT. The relationship was well explained by both linear regression (R 2 = 0.179, P = 0.004) and fractional polynomial analysis (R 2 = 0.275, P = 0.001). When we performed an assessment by linear regression with an indicator, the relationship was significant both in the healthy and AD groups, with a stronger correlation found in the healthy group (regression coefficients = -1.098 vs. -0.280, P = 0.018). Conclusions: An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remains to be determined.

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