Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis

T. Shin; D. S. Min; M. Ahn; W. Son; Y. Matsumoto

doi:10.1081/IMM-120016238

Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis

T. Shin, D. S. Min, M. Ahn, W. Son, Y. Matsumoto

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.

Original language	English
Pages (from-to)	169-176
Number of pages	8
Journal	Immunological Investigations
Volume	31
Issue number	3-4
DOIs	https://doi.org/10.1081/IMM-120016238
Publication status	Published - 2002

Bibliographical note

Funding Information:
This work was supported by a grant from the Cheongbong Academic Research Fund of the Cheju National University Development Foundation.

All Science Journal Classification (ASJC) codes

Immunology

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10.1081/IMM-120016238

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title = "Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis",

abstract = "Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.",

author = "T. Shin and Min, {D. S.} and M. Ahn and W. Son and Y. Matsumoto",

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T1 - Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis

AU - Shin, T.

AU - Min, D. S.

AU - Ahn, M.

AU - Son, W.

AU - Matsumoto, Y.

N1 - Funding Information: This work was supported by a grant from the Cheongbong Academic Research Fund of the Cheju National University Development Foundation.

PY - 2002

Y1 - 2002

N2 - Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.

AB - Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.

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Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis

Abstract

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