Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis

T. Shin, D. S. Min, M. Ahn, W. Son, Y. Matsumoto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats. PLD1 immunoreactivity was seen in some Schwann cells in the sciatic nerves of normal rats. In parallel with the progression of EAN, PLD1-positive Schwann cells significantly increased in number and showed intense immunoreactivity. PLD1 was also detected in some ED1+ macrophages in EAN lesions. These results suggest that PLD1 in macrophages and Schwann cells plays an important role in the activation of these cells in the pathogenesis of EAN, an animal model of human peripheral demyelinating disease.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalImmunological Investigations
Volume31
Issue number3-4
DOIs
Publication statusPublished - 2002 Jan 1

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Experimental Autoimmune Neuritis
Sciatic Nerve
Schwann Cells
Macrophages
Demyelinating Diseases
Animal Models
phospholipase D1

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

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Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis. / Shin, T.; Min, D. S.; Ahn, M.; Son, W.; Matsumoto, Y.

In: Immunological Investigations, Vol. 31, No. 3-4, 01.01.2002, p. 169-176.

Research output: Contribution to journalArticle

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