Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients

Kyoung Hoon Jeong, Se Hoon Kim, Yun Ho Choi, Inja Cho, Won Joo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Granule cell dispersion (GCD) is a common neuropathological feature of hippocampal sclerosis (HS) in patients with temporal lobe epilepsy (TLE). However, the underlying molecular mechanism of GCD formation remains unclear. The present study aimed to investigate the expressional changes of With No Lysine protein kinase subtype 3 (WNK3), a molecule upstream of cation-chloride cotransporters with reciprocal expression in sclerosed hippocampus of TLE patients. Using immunofluorescence staining, we analyzed WNK3 immunoreactivity in hippocampal specimens from histologically normal controls and TLE patients with HS. Our results showed that WNK3 expression was significantly increased in dispersed granule neurons in hippocampal tissues from patients with TLE compared with histologically normal hippocampus. These findings demonstrate a potential association between an increased expression of WNK3 and GCD formation during the chronic phase of epilepsy. Controlling WNK3 expression may thus be a novel therapeutic target in epileptogenesis.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalEpilepsy Research
Volume147
DOIs
Publication statusPublished - 2018 Nov

Bibliographical note

Funding Information:
This research was supported by National Research Foundation of Korea (NRF) grants funded by the Korean government ( 2015R1D1A1A01059901 , 2018R1D1A1B07046708 , and 2018R1D1A1B07047059 ).

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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