Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance

Jong Chan Youn, Min Kyung Jung, Hee Tae Yu, Ji Soo Kwon, Jeong Eun Kwak, Su Hyung Park, In Cheol Kim, Myung Soo Park, Sun Ki Lee, Suk Won Choi, Seongwoo Han, Kyu Hyung Ryu, Seok Min Kang, Eui Cheol Shin

Research output: Contribution to journalArticle

Abstract

Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57 T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.

Original languageEnglish
Article number12887
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Heart Failure
T-Lymphocytes
T-Lymphocyte Subsets
Population
Heart Transplantation
Interleukin-6
Healthy Volunteers
Mortality

All Science Journal Classification (ASJC) codes

  • General

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Youn, Jong Chan ; Jung, Min Kyung ; Yu, Hee Tae ; Kwon, Ji Soo ; Kwak, Jeong Eun ; Park, Su Hyung ; Kim, In Cheol ; Park, Myung Soo ; Lee, Sun Ki ; Choi, Suk Won ; Han, Seongwoo ; Ryu, Kyu Hyung ; Kang, Seok Min ; Shin, Eui Cheol. / Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure : exploring new pathogenic mechanisms with clinical relevance. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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title = "Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance",
abstract = "Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.",
author = "Youn, {Jong Chan} and Jung, {Min Kyung} and Yu, {Hee Tae} and Kwon, {Ji Soo} and Kwak, {Jeong Eun} and Park, {Su Hyung} and Kim, {In Cheol} and Park, {Myung Soo} and Lee, {Sun Ki} and Choi, {Suk Won} and Seongwoo Han and Ryu, {Kyu Hyung} and Kang, {Seok Min} and Shin, {Eui Cheol}",
year = "2019",
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Youn, JC, Jung, MK, Yu, HT, Kwon, JS, Kwak, JE, Park, SH, Kim, IC, Park, MS, Lee, SK, Choi, SW, Han, S, Ryu, KH, Kang, SM & Shin, EC 2019, 'Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance', Scientific reports, vol. 9, no. 1, 12887. https://doi.org/10.1038/s41598-019-49332-5

Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure : exploring new pathogenic mechanisms with clinical relevance. / Youn, Jong Chan; Jung, Min Kyung; Yu, Hee Tae; Kwon, Ji Soo; Kwak, Jeong Eun; Park, Su Hyung; Kim, In Cheol; Park, Myung Soo; Lee, Sun Ki; Choi, Suk Won; Han, Seongwoo; Ryu, Kyu Hyung; Kang, Seok Min; Shin, Eui Cheol.

In: Scientific reports, Vol. 9, No. 1, 12887, 01.12.2019.

Research output: Contribution to journalArticle

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T1 - Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure

T2 - exploring new pathogenic mechanisms with clinical relevance

AU - Youn, Jong Chan

AU - Jung, Min Kyung

AU - Yu, Hee Tae

AU - Kwon, Ji Soo

AU - Kwak, Jeong Eun

AU - Park, Su Hyung

AU - Kim, In Cheol

AU - Park, Myung Soo

AU - Lee, Sun Ki

AU - Choi, Suk Won

AU - Han, Seongwoo

AU - Ryu, Kyu Hyung

AU - Kang, Seok Min

AU - Shin, Eui Cheol

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.

AB - Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.

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