Increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients

In Soo Kim, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, SangKil Lee, Yongchan Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aims: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whether there was a high incidence of endoscopic findings of EE in solid organ transplant recipients. Methods: This retrospective case-control study included 256 of 3,152 solid organ transplant recipients who underwent sequential screening upper endoscopic examinations and an equal number of controls. Results: Forty-four (17.2%) and 16 (6.2%) cases of EE were detected in the solid organ transplant and control groups, respectively (p<0.001). In the multivariate analysis, transplantation was significantly associated with EE (odds ratio [OR], 6.48; 95% confidence interval, 2.74 to 15.35). Factors such as old age (OR, 1.17), the presence of a hiatal hernia (OR, 5.84), an increased duration of immunosuppression (OR, 1.07), and the maintenance administration of mycophenolate mofetil (OR, 4.13) were independently associated with the occurrence of EE in the solid organ transplant recipients. Conclusions: A significant increase in the incidence of endoscopically detected EE was observed in solid organ transplant recipients. This increased incidence was associated with the type and duration of the immunosuppressive therapy.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalGut and liver
Volume6
Issue number3
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Esophagitis
Transplants
Odds Ratio
Incidence
Transplantation
Mycophenolic Acid
Heartburn
Hiatal Hernia
Dyspepsia
Immunosuppressive Agents
Immunosuppression
Transplant Recipients
Case-Control Studies
Multivariate Analysis
Maintenance
Confidence Intervals
Control Groups

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology

Cite this

Kim, In Soo ; Lee, Hyuk ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, SangKil ; Lee, Yongchan. / Increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients. In: Gut and liver. 2012 ; Vol. 6, No. 3. pp. 349-354.
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Increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients. / Kim, In Soo; Lee, Hyuk; Park, Jun Chul; Shin, Sung Kwan; Lee, SangKil; Lee, Yongchan.

In: Gut and liver, Vol. 6, No. 3, 01.07.2012, p. 349-354.

Research output: Contribution to journalArticle

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