Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

Marco Gallo, Donha Park, Donald L. Riddle

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalMechanisms of Ageing and Development
Volume132
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

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Up-Regulation
Caenorhabditis elegans
Oxidative Stress
Phenotype
Genes
glyoxylic acid

All Science Journal Classification (ASJC) codes

  • Ageing
  • Developmental Biology

Cite this

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Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. / Gallo, Marco; Park, Donha; Riddle, Donald L.

In: Mechanisms of Ageing and Development, Vol. 132, No. 10, 01.10.2011, p. 515-518.

Research output: Contribution to journalArticle

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