Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals

Minjoo Kim, Jean Kyung Paik, Ryungwoo Kang, Soo Young Kim, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS). Materials/Methods: Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F (8-epi-PGF) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n = 569) or absence (n = 1277) of MetS and by BMI (18.5-24.9 kg/m2 = normal weight, n = 1254; ≥ 25 kg/m2 = overweight/obese, n = 592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Compared to normal weight women with MetS (n = 296), metabolically healthy overweight/obese women (n = 319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n = 958) but was lower than in women with MetS. Urinary 8-epi-PGF level was about 11% lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95% CI: 1.65-3.55) and 8-epi-PGF (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF. Conclusions: The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF.

Original languageEnglish
Pages (from-to)554-560
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume62
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

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Oxidative Stress
Weights and Measures
Dinoprost
Odds Ratio
Phenotype
Metabolome
Adiponectin
Particle Size
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Drinking
Blood Glucose
oxidized low density lipoprotein
Triglycerides
Cross-Sectional Studies
Smoking
Cholesterol
Blood Pressure
Education

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{cd6fae10245e41f28f68c51cd1aa2ea8,
title = "Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals",
abstract = "Objective: The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS). Materials/Methods: Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n = 569) or absence (n = 1277) of MetS and by BMI (18.5-24.9 kg/m2 = normal weight, n = 1254; ≥ 25 kg/m2 = overweight/obese, n = 592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Compared to normal weight women with MetS (n = 296), metabolically healthy overweight/obese women (n = 319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n = 958) but was lower than in women with MetS. Urinary 8-epi-PGF2α level was about 11{\%} lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95{\%} CI: 1.65-3.55) and 8-epi-PGF2α (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF2α. Conclusions: The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF2α.",
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Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals. / Kim, Minjoo; Paik, Jean Kyung; Kang, Ryungwoo; Kim, Soo Young; Lee, Sang Hyun; Lee, Jong Ho.

In: Metabolism: Clinical and Experimental, Vol. 62, No. 4, 01.04.2013, p. 554-560.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals

AU - Kim, Minjoo

AU - Paik, Jean Kyung

AU - Kang, Ryungwoo

AU - Kim, Soo Young

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

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N2 - Objective: The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS). Materials/Methods: Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n = 569) or absence (n = 1277) of MetS and by BMI (18.5-24.9 kg/m2 = normal weight, n = 1254; ≥ 25 kg/m2 = overweight/obese, n = 592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Compared to normal weight women with MetS (n = 296), metabolically healthy overweight/obese women (n = 319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n = 958) but was lower than in women with MetS. Urinary 8-epi-PGF2α level was about 11% lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95% CI: 1.65-3.55) and 8-epi-PGF2α (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF2α. Conclusions: The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF2α.

AB - Objective: The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS). Materials/Methods: Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n = 569) or absence (n = 1277) of MetS and by BMI (18.5-24.9 kg/m2 = normal weight, n = 1254; ≥ 25 kg/m2 = overweight/obese, n = 592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Compared to normal weight women with MetS (n = 296), metabolically healthy overweight/obese women (n = 319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n = 958) but was lower than in women with MetS. Urinary 8-epi-PGF2α level was about 11% lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95% CI: 1.65-3.55) and 8-epi-PGF2α (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF2α. Conclusions: The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF2α.

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