Increased Plasma Aldosterone-to-Renin Ratio Is Associated with Impaired Left Ventricular Longitudinal Functional Reserve in Patients with Uncomplicated Hypertension

Eui Young Choi, Jong Won Ha, Se Jung Yoon, ChiYoung Shim, Hye Sun Seo, Sungha Park, Young Guk Ko, seokmin kang, Donghoon Choi, Se Joong Rim, Yangsoo Jang, Namsik Chung

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5 Citations (Scopus)

Abstract

Relative aldosterone excess is associated with endothelial dysfunction and higher incidence of end organ damage. We sought to investigate whether plasma aldosterone-to-renin ratio (ARR) is associated with left ventricular (LV) longitudinal function reserve to exercise in patients with controlled hypertension. In the patients with controlled and uncomplicated hypertension without overt LV hypertrophy, plasma aldosterone concentrations (ng/dL) and renin activities (ng/mL/h) were measured. Then 28 consecutive patients with higher ARR (group II, ARR ≥ 30, 55 ± 10 years) and 56 age- and sex-matched patients with lower ARR (group I, ARR < 30) underwent supine bicycle exercise echocardiography. Despite similar 24-hour blood pressure, LV mass index was significantly higher in group II (91.1 ± 16.4 vs 101.7 ± 18.2 g/m2, P = .008). Early diastolic and systolic mitral annular velocity (E' and S', cm/s) at 50-W exercise was significantly lower in group II compared with group I (9.91 ± 1.66 vs 8.67 ± 1.65 cm/s, P = .002; 9.52 ± 1.71 vs 8.46 ± 1.79, P = .010, respectively) despite similar resting values. Longitudinal diastolic functional reserve at 25-W and 50-W exercise, defined as ΔE' (change from resting E', cm/s) of group II was significantly lower than that of group I (2.60 ± 1.42 vs 1.85 ± 1.44 cm/s, P = .016; 3.40 ± 1.48 vs 2.36 ± 1.43 cm/s, P = .003, respectively). In conclusion, in patients with hypertension without overt LV hypertrophy, increased ARR is associated with increased LV mass, and impaired LV longitudinal functional reserve during exercise.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume21
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

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Aldosterone
Renin
Hypertension
Exercise
Left Ventricular Hypertrophy
Left Ventricular Function
Echocardiography
Blood Pressure
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Increased Plasma Aldosterone-to-Renin Ratio Is Associated with Impaired Left Ventricular Longitudinal Functional Reserve in Patients with Uncomplicated Hypertension",
abstract = "Relative aldosterone excess is associated with endothelial dysfunction and higher incidence of end organ damage. We sought to investigate whether plasma aldosterone-to-renin ratio (ARR) is associated with left ventricular (LV) longitudinal function reserve to exercise in patients with controlled hypertension. In the patients with controlled and uncomplicated hypertension without overt LV hypertrophy, plasma aldosterone concentrations (ng/dL) and renin activities (ng/mL/h) were measured. Then 28 consecutive patients with higher ARR (group II, ARR ≥ 30, 55 ± 10 years) and 56 age- and sex-matched patients with lower ARR (group I, ARR < 30) underwent supine bicycle exercise echocardiography. Despite similar 24-hour blood pressure, LV mass index was significantly higher in group II (91.1 ± 16.4 vs 101.7 ± 18.2 g/m2, P = .008). Early diastolic and systolic mitral annular velocity (E' and S', cm/s) at 50-W exercise was significantly lower in group II compared with group I (9.91 ± 1.66 vs 8.67 ± 1.65 cm/s, P = .002; 9.52 ± 1.71 vs 8.46 ± 1.79, P = .010, respectively) despite similar resting values. Longitudinal diastolic functional reserve at 25-W and 50-W exercise, defined as ΔE' (change from resting E', cm/s) of group II was significantly lower than that of group I (2.60 ± 1.42 vs 1.85 ± 1.44 cm/s, P = .016; 3.40 ± 1.48 vs 2.36 ± 1.43 cm/s, P = .003, respectively). In conclusion, in patients with hypertension without overt LV hypertrophy, increased ARR is associated with increased LV mass, and impaired LV longitudinal functional reserve during exercise.",
author = "Choi, {Eui Young} and Ha, {Jong Won} and Yoon, {Se Jung} and ChiYoung Shim and Seo, {Hye Sun} and Sungha Park and Ko, {Young Guk} and seokmin kang and Donghoon Choi and Rim, {Se Joong} and Yangsoo Jang and Namsik Chung",
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Increased Plasma Aldosterone-to-Renin Ratio Is Associated with Impaired Left Ventricular Longitudinal Functional Reserve in Patients with Uncomplicated Hypertension. / Choi, Eui Young; Ha, Jong Won; Yoon, Se Jung; Shim, ChiYoung; Seo, Hye Sun; Park, Sungha; Ko, Young Guk; kang, seokmin; Choi, Donghoon; Rim, Se Joong; Jang, Yangsoo; Chung, Namsik.

In: Journal of the American Society of Echocardiography, Vol. 21, No. 3, 01.03.2008, p. 251-256.

Research output: Contribution to journalArticle

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T1 - Increased Plasma Aldosterone-to-Renin Ratio Is Associated with Impaired Left Ventricular Longitudinal Functional Reserve in Patients with Uncomplicated Hypertension

AU - Choi, Eui Young

AU - Ha, Jong Won

AU - Yoon, Se Jung

AU - Shim, ChiYoung

AU - Seo, Hye Sun

AU - Park, Sungha

AU - Ko, Young Guk

AU - kang, seokmin

AU - Choi, Donghoon

AU - Rim, Se Joong

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2008/3/1

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N2 - Relative aldosterone excess is associated with endothelial dysfunction and higher incidence of end organ damage. We sought to investigate whether plasma aldosterone-to-renin ratio (ARR) is associated with left ventricular (LV) longitudinal function reserve to exercise in patients with controlled hypertension. In the patients with controlled and uncomplicated hypertension without overt LV hypertrophy, plasma aldosterone concentrations (ng/dL) and renin activities (ng/mL/h) were measured. Then 28 consecutive patients with higher ARR (group II, ARR ≥ 30, 55 ± 10 years) and 56 age- and sex-matched patients with lower ARR (group I, ARR < 30) underwent supine bicycle exercise echocardiography. Despite similar 24-hour blood pressure, LV mass index was significantly higher in group II (91.1 ± 16.4 vs 101.7 ± 18.2 g/m2, P = .008). Early diastolic and systolic mitral annular velocity (E' and S', cm/s) at 50-W exercise was significantly lower in group II compared with group I (9.91 ± 1.66 vs 8.67 ± 1.65 cm/s, P = .002; 9.52 ± 1.71 vs 8.46 ± 1.79, P = .010, respectively) despite similar resting values. Longitudinal diastolic functional reserve at 25-W and 50-W exercise, defined as ΔE' (change from resting E', cm/s) of group II was significantly lower than that of group I (2.60 ± 1.42 vs 1.85 ± 1.44 cm/s, P = .016; 3.40 ± 1.48 vs 2.36 ± 1.43 cm/s, P = .003, respectively). In conclusion, in patients with hypertension without overt LV hypertrophy, increased ARR is associated with increased LV mass, and impaired LV longitudinal functional reserve during exercise.

AB - Relative aldosterone excess is associated with endothelial dysfunction and higher incidence of end organ damage. We sought to investigate whether plasma aldosterone-to-renin ratio (ARR) is associated with left ventricular (LV) longitudinal function reserve to exercise in patients with controlled hypertension. In the patients with controlled and uncomplicated hypertension without overt LV hypertrophy, plasma aldosterone concentrations (ng/dL) and renin activities (ng/mL/h) were measured. Then 28 consecutive patients with higher ARR (group II, ARR ≥ 30, 55 ± 10 years) and 56 age- and sex-matched patients with lower ARR (group I, ARR < 30) underwent supine bicycle exercise echocardiography. Despite similar 24-hour blood pressure, LV mass index was significantly higher in group II (91.1 ± 16.4 vs 101.7 ± 18.2 g/m2, P = .008). Early diastolic and systolic mitral annular velocity (E' and S', cm/s) at 50-W exercise was significantly lower in group II compared with group I (9.91 ± 1.66 vs 8.67 ± 1.65 cm/s, P = .002; 9.52 ± 1.71 vs 8.46 ± 1.79, P = .010, respectively) despite similar resting values. Longitudinal diastolic functional reserve at 25-W and 50-W exercise, defined as ΔE' (change from resting E', cm/s) of group II was significantly lower than that of group I (2.60 ± 1.42 vs 1.85 ± 1.44 cm/s, P = .016; 3.40 ± 1.48 vs 2.36 ± 1.43 cm/s, P = .003, respectively). In conclusion, in patients with hypertension without overt LV hypertrophy, increased ARR is associated with increased LV mass, and impaired LV longitudinal functional reserve during exercise.

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